13 February 2019
Vol 11, Issue 479

About The Cover

Cover image expansion

ONLINE COVER Platelets in Disguise. Platelet hyperactivation plays a principal role in thrombotic events and contributes to formation of tumor metastases. Current drugs that prevent platelet activation are associated with an increased risk of adverse events due to the long time required to reverse the drugs' effects. Rapidly reversible platelet inhibitors called platelet decoys (pictured here) have been developed by modifying human platelets (Papa et al.). Although platelet decoys cannot become activated, they still retain their ability to bind to other cell types. Platelet decoys showed antithrombotic effects in rabbits and reduced tumor metastases in mice. The antiplatelet effect was rapidly reversed by administration of normal human platelets. [CREDIT: PAPA ET AL./SCIENCE TRANSLATIONAL MEDICINE]