Research ArticleCancer

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity

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Science Translational Medicine  06 Feb 2019:
Vol. 11, Issue 478, eaau8866
DOI: 10.1126/scitranslmed.aau8866

Article Information

vol. 11 no. 478

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 30, 2018
  • Accepted for publication December 28, 2018

Author Information

  1. Bruno Saleme1,2,
  2. Vikram Gurtu1,2,
  3. Yongneng Zhang1,2,
  4. Adam Kinnaird1,3,
  5. Aristeidis E. Boukouris1,2,
  6. Keshav Gopal2,4,
  7. John R. Ussher2,4 and
  8. Gopinath Sutendra1,2,5,*
  1. 1Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
  2. 2Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
  3. 3Department of Surgery, University of Alberta, Edmonton, Alberta T6G 1Z1, Canada.
  4. 4Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H1, Canada.
  5. 5Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.
  1. *Corresponding author. Email: sutendra{at}ualberta.ca

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Article usage: February 2019 to April 2019

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Feb 201957031079541
Mar 2019575124101
Apr 20193778260