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Research ArticlePEDIATRICS
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
- Jennifer M. Dan1,2,
- Colin Havenar-Daughton1,3,
- Kayla Kendric1,
- Rita Al-kolla1,
- Kirti Kaushik1,
- Sandy L. Rosales1,
- Ericka L. Anderson4,5,6,
- Christopher N. LaRock4,5,7,
- Pandurangan Vijayanand1,
- Grégory Seumois1,
- David Layfield8,
- Ramsey I. Cutress8,
- Christian H. Ottensmeier8,
- Cecilia S. Lindestam Arlehamn1,
- Alessandro Sette1,2,
- Victor Nizet4,5,
- Marcella Bothwell9,10,11,
- Matthew Brigger9,10,11 and
- Shane Crotty1,2,3,*
- 1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
- 2Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
- 3Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.
- 4Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.
- 5Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.
- 6Human Longevity Inc., San Diego, CA 92121, USA.
- 7Department of Microbiology and Immunology, Emory School of Medicine, Atlanta, GA 30322, USA.
- 8Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.
- 9Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.
- 10Department of Surgery, UCSD, La Jolla, CA 92037, USA.
- 11Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.
- ↵*Corresponding author. Email: shane{at}lji.org
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Science Translational Medicine 06 Feb 2019:
Vol. 11, Issue 478, eaau3776
DOI: 10.1126/scitranslmed.aau3776
Vol. 11, Issue 478, eaau3776
DOI: 10.1126/scitranslmed.aau3776
Jennifer M. Dan
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Colin Havenar-Daughton
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.
Kayla Kendric
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Rita Al-kolla
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Kirti Kaushik
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Sandy L. Rosales
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Ericka L. Anderson
Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.Human Longevity Inc., San Diego, CA 92121, USA.
Christopher N. LaRock
Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.Department of Microbiology and Immunology, Emory School of Medicine, Atlanta, GA 30322, USA.
Pandurangan Vijayanand
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Grégory Seumois
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
David Layfield
Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.
Ramsey I. Cutress
Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.
Christian H. Ottensmeier
Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.
Cecilia S. Lindestam Arlehamn
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Alessandro Sette
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Victor Nizet
Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.
Marcella Bothwell
Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.Department of Surgery, UCSD, La Jolla, CA 92037, USA.Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.
Matthew Brigger
Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.Department of Surgery, UCSD, La Jolla, CA 92037, USA.Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.
Shane Crotty
Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.
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