Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells

Jennifer M. Dan; Colin Havenar-Daughton; Kayla Kendric; Rita Al-kolla; Kirti Kaushik; Sandy L. Rosales; Ericka L. Anderson; Christopher N. LaRock; Pandurangan Vijayanand; Grégory Seumois; David Layfield; Ramsey I. Cutress; Christian H. Ottensmeier; Cecilia S. Lindestam Arlehamn; Alessandro Sette; Victor Nizet; Marcella Bothwell; Matthew Brigger; Shane Crotty

doi:10.1126/scitranslmed.aau3776

Research ArticlePEDIATRICS

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant T_FH cells

Jennifer M. Dan ¹,²,
Colin Havenar-Daughton¹,³,
Kayla Kendric¹,
Rita Al-kolla¹,
Kirti Kaushik¹,
Sandy L. Rosales¹,
Ericka L. Anderson⁴,⁵,⁶,
Christopher N. LaRock⁴,⁵,⁷,
Pandurangan Vijayanand¹,
Grégory Seumois¹,
David Layfield⁸,
Ramsey I. Cutress⁸,
Christian H. Ottensmeier ⁸,
Cecilia S. Lindestam Arlehamn¹,
Alessandro Sette¹,²,
Victor Nizet ⁴,⁵,
Marcella Bothwell⁹,¹⁰,¹¹,
Matthew Brigger⁹,¹⁰,¹¹ and
Shane Crotty ¹,²,³,*

¹Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
²Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
³Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.
⁴Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.
⁵Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.
⁶Human Longevity Inc., San Diego, CA 92121, USA.
⁷Department of Microbiology and Immunology, Emory School of Medicine, Atlanta, GA 30322, USA.
⁸Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.
⁹Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.
¹⁰Department of Surgery, UCSD, La Jolla, CA 92037, USA.
¹¹Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.

↵*Corresponding author. Email: shane{at}lji.org

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Science Translational Medicine 06 Feb 2019:
Vol. 11, Issue 478, eaau3776
DOI: 10.1126/scitranslmed.aau3776

Jennifer M. Dan

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

2Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.

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Colin Havenar-Daughton

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

3Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.

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Kayla Kendric

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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Rita Al-kolla

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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Kirti Kaushik

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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Sandy L. Rosales

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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Ericka L. Anderson

4Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.

5Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.

6Human Longevity Inc., San Diego, CA 92121, USA.

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Christopher N. LaRock

4Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.

5Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.

7Department of Microbiology and Immunology, Emory School of Medicine, Atlanta, GA 30322, USA.

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Pandurangan Vijayanand

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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Grégory Seumois

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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David Layfield

8Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.

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Ramsey I. Cutress

8Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.

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Christian H. Ottensmeier

8Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.

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Cecilia S. Lindestam Arlehamn

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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Alessandro Sette

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

2Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.

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Victor Nizet

4Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.

5Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.

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Marcella Bothwell

9Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.

10Department of Surgery, UCSD, La Jolla, CA 92037, USA.

11Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.

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Matthew Brigger

9Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.

10Department of Surgery, UCSD, La Jolla, CA 92037, USA.

11Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.

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Shane Crotty

1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

2Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.

3Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.

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For correspondence: shane@lji.org

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Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant T_FH cells

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