Research ArticlePEDIATRICS

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells

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Science Translational Medicine  06 Feb 2019:
Vol. 11, Issue 478, eaau3776
DOI: 10.1126/scitranslmed.aau3776

Article Information

vol. 11 no. 478

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Online ISSN: 
  • Received for publication June 4, 2018
  • Resubmitted September 29, 2018
  • Accepted for publication January 11, 2019

Author Information

  1. Jennifer M. Dan1,2,
  2. Colin Havenar-Daughton1,3,
  3. Kayla Kendric1,
  4. Rita Al-kolla1,
  5. Kirti Kaushik1,
  6. Sandy L. Rosales1,
  7. Ericka L. Anderson4,5,6,
  8. Christopher N. LaRock4,5,7,
  9. Pandurangan Vijayanand1,
  10. Grégory Seumois1,
  11. David Layfield8,
  12. Ramsey I. Cutress8,
  13. Christian H. Ottensmeier8,
  14. Cecilia S. Lindestam Arlehamn1,
  15. Alessandro Sette1,2,
  16. Victor Nizet4,5,
  17. Marcella Bothwell9,10,11,
  18. Matthew Brigger9,10,11 and
  19. Shane Crotty1,2,3,*
  1. 1Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
  2. 2Department of Medicine, Division of Infectious Diseases, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
  3. 3Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA.
  4. 4Department of Pediatrics, School of Medicine, UCSD, La Jolla, CA 92037, USA.
  5. 5Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA 92037, USA.
  6. 6Human Longevity Inc., San Diego, CA 92121, USA.
  7. 7Department of Microbiology and Immunology, Emory School of Medicine, Atlanta, GA 30322, USA.
  8. 8Cancer Sciences Division, Faculty of Medicine, University of Southampton, UK.
  9. 9Division of Pediatric Otolaryngology, Rady Children’s Hospital, San Diego, CA 92123, USA.
  10. 10Department of Surgery, UCSD, La Jolla, CA 92037, USA.
  11. 11Department of Otolaryngology, Head and Neck Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.
  1. *Corresponding author. Email: shane{at}


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