Focus10TH ANNIVERSARY SERIES

Transforming medicine with the microbiome

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Science Translational Medicine  30 Jan 2019:
Vol. 11, Issue 477, eaaw1815
DOI: 10.1126/scitranslmed.aaw1815

Figures

  • Fig. 1 Gut microbiome–based therapeutic approaches.

    Recent research has elucidated gut microbiome interventions for promoting human health and for combating disease. These approaches include microbiome modulation or direct impact on the host through nutritional intervention, either by prebiotics or by individualized diets (top left). Strategies to affect the gut microbiome or directly impact the host through live bacteria supplementation or exclusion include fecal microbiome transplantation (FMT), treatment with custom-made probiotics, or targeted elimination of bacterial members of the microbiome (top right). The host and potentially its microbiome can also be modulated by administration, reduction, or activity blocking of bacteria-derived metabolites through treatment with or inhibition of postbiotics (bottom right) or by manipulation of host gut barrier function (bottom left). Collectively, these modalities, when used alone or in combinations, will affect the host-microbiome interface.

    CREDIT: A. KITTERMAN/SCIENCE TRANSLATIONAL MEDICINE

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