Research ArticleNeuroblastoma

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

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Science Translational Medicine  30 Jan 2019:
Vol. 11, Issue 477, eaau1099
DOI: 10.1126/scitranslmed.aau1099

Article Information

vol. 11 no. 477

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 16, 2018
  • Accepted for publication January 8, 2019

Author Information

  1. Laura D. Gamble1,*,
  2. Stefania Purgato2,*,
  3. Jayne Murray1,
  4. Lin Xiao1,
  5. Denise M. T. Yu1,3,
  6. Kimberley M. Hanssen1,3,
  7. Federico M. Giorgi2,
  8. Daniel R. Carter1,3,4,
  9. Andrew J. Gifford1,3,5,
  10. Emanuele Valli1,3,
  11. Giorgio Milazzo2,
  12. Alvin Kamili1,3,
  13. Chelsea Mayoh1,3,
  14. Bing Liu1,
  15. Georgina Eden1,
  16. Sara Sarraf1,
  17. Sophie Allan1,
  18. Simone Di Giacomo2,
  19. Claudia L. Flemming1,
  20. Amanda J. Russell6,
  21. Belamy B. Cheung1,3,
  22. Andre Oberthuer7,
  23. Wendy B. London8,
  24. Matthias Fischer7,
  25. Toby N. Trahair1,3,9,
  26. Jamie I. Fletcher1,3,
  27. Glenn M. Marshall1,3,9,
  28. David S. Ziegler1,3,9,
  29. Michael D. Hogarty10,
  30. Mark R. Burns11,
  31. Giovanni Perini2,,
  32. Murray D. Norris1,12, and
  33. Michelle Haber1,3,,
  1. 1Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.
  2. 2Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy.
  3. 3School of Women’s & Children’s Health, UNSW Australia, Randwick, NSW 2052, Australia.
  4. 4School of Biomedical Engineering, University of Technology, Sydney, NSW 2007, Australia.
  5. 5Department of Anatomical Pathology (SEALS), Prince of Wales Hospital, Randwick, NSW 2031, Australia.
  6. 6Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  7. 7Children's Hospital, Department of Pediatric Oncology and Hematology, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany.
  8. 8Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA 02215, USA.
  9. 9Kids Cancer Centre, Sydney Children’s Hospital, High Street, Randwick, NSW 2031, Australia.
  10. 10Division of Oncology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA.
  11. 11Aminex Therapeutics, Aminex Therapeutics Inc., Kirkland, WA 98034, USA.
  12. 12University of New South Wales Centre for Childhood Cancer Research, Sydney, NSW 2052, Australia.
  1. Corresponding author. Email: mhaber{at}ccia.unsw.edu.au
  • * These authors contributed equally to this work as first authors.

  • These authors contributed equally to this work as last authors.

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