Research ArticleBIOMATERIALS

A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

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Science Translational Medicine  30 Jan 2019:
Vol. 11, Issue 477, eaat7973
DOI: 10.1126/scitranslmed.aat7973

Article Information

vol. 11 no. 477

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History: 
  • Received for publication April 5, 2018
  • Resubmitted October 12, 2018
  • Accepted for publication December 18, 2018
  • .

Author Information

  1. Matthew T. Wolf1,2,3,
  2. Sudipto Ganguly2,4,
  3. Tony L. Wang1,5,
  4. Christopher W. Anderson6,
  5. Kaitlyn Sadtler7,8,
  6. Radhika Narain1,5,
  7. Christopher Cherry1,5,
  8. Alexis J. Parrillo1,5,
  9. Benjamin V. Park9,
  10. Guannan Wang4,
  11. Fan Pan2,4,
  12. Saraswati Sukumar4,
  13. Drew M. Pardoll2,4 and
  14. Jennifer H. Elisseeff1,2,3,5,*
  1. 1Translational Tissue Engineering Center, Baltimore, MD 21231, USA.
  2. 2Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD 21287, USA.
  3. 3Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  4. 4Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  5. 5Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  6. 6Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06511, USA.
  7. 7David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  8. 8Department of Anesthesiology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  9. 9University of Illinois College of Medicine, Chicago, IL 60612, USA.
  1. *Corresponding author. Email: jhe{at}jhu.edu

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