Research ArticleKidney Fibrosis

Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair

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Science Translational Medicine  23 Jan 2019:
Vol. 11, Issue 476, eaav4754
DOI: 10.1126/scitranslmed.aav4754

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Taking kidney fibrosis to TASCC

The kidney has an inherent capacity to recover from acute injury; however, severe injury can lead to chronic kidney disease and fibrosis. Canaud et al. studied kidney epithelial cells’ maladaptive response to injury. The formation of target of rapamycin–autophagy spatial coupling compartments (TASCCs) in proximal epithelial cells was associated with cell cycle arrest and fibrosis in human chronic kidney disease, whereas knocking out cyclin G1 prevented TASCC formation and fibrosis in mouse models. This study provides mechanistic insight into renal fibrosis and identifies a potential therapeutic target.