Research ArticleMetabolism
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
- View ORCID ProfileCaroline B. Kurtz1,*,
- Yves A. Millet1,†,
- Marja K. Puurunen1,
- Mylène Perreault1,
- Mark R. Charbonneau1,
- View ORCID ProfileVincent M. Isabella1,
- Jonathan W. Kotula1,‡,
- Eugene Antipov1,
- Yossi Dagon1,
- View ORCID ProfileWilliam S. Denney2,
- View ORCID ProfileDavid A. Wagner3,
- View ORCID ProfileKip A. West1,
- Andrew J. Degar4,
- Aoife M. Brennan1 and
- View ORCID ProfilePaul F. Miller1
- 1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
- 2Human Predictions LLC, 649 Massachusetts Avenue Suite 6, Cambridge, MA 02139, USA.
- 3Metabolic Solutions Inc., 460 Amherst Street, Nashua, NH 03063, USA.
- 4Diversigen Inc., 1 Baylor Plaza, Houston, TX 77030, USA.
- ↵*Corresponding author. Email: caroline{at}synlogictx.com
See allHide authors and affiliations
Science Translational Medicine 16 Jan 2019:
Vol. 11, Issue 475, eaau7975
DOI: 10.1126/scitranslmed.aau7975
Vol. 11, Issue 475, eaau7975
DOI: 10.1126/scitranslmed.aau7975
Caroline B. Kurtz
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Yves A. Millet
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Marja K. Puurunen
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Mylène Perreault
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Mark R. Charbonneau
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Vincent M. Isabella
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Jonathan W. Kotula
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Eugene Antipov
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Yossi Dagon
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
William S. Denney
4Diversigen Inc., 1 Baylor Plaza, Houston, TX 77030, USA.
David A. Wagner
3Metabolic Solutions Inc., 460 Amherst Street, Nashua, NH 03063, USA.
Kip A. West
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Andrew J. Degar
4Diversigen Inc., 1 Baylor Plaza, Houston, TX 77030, USA.
Aoife M. Brennan
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
Paul F. Miller
1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
