An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

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  An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

  By Caroline B. Kurtz, Yves A. Millet, Marja K. Puurunen, Mylène Perreault, Mark R. Charbonneau, Vincent M. Isabella, Jonathan W. Kotula, Eugene Antipov, Yossi Dagon, William S. Denney, David A. Wagner, Kip A. West, Andrew J. Degar, Aoife M. Brennan, Paul F. Miller

  Science Translational Medicine16 Jan 2019

  An engineered E. coli strain lowers blood ammonia, improves survival in models of hyperammonemia, and demonstrates safety in healthy volunteers.

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  An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

  By Caroline B. Kurtz, Yves A. Millet, Marja K. Puurunen, Mylène Perreault, Mark R. Charbonneau, Vincent M. Isabella, Jonathan W. Kotula, Eugene Antipov, Yossi Dagon, William S. Denney, David A. Wagner, Kip A. West, Andrew J. Degar, Aoife M. Brennan, Paul F. Miller

  Science Translational Medicine16 Jan 2019

  An engineered E. coli strain lowers blood ammonia, improves survival in models of hyperammonemia, and demonstrates safety in healthy volunteers.

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