Research ArticleMetabolism

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

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Science Translational Medicine  16 Jan 2019:
Vol. 11, Issue 475, eaau7975
DOI: 10.1126/scitranslmed.aau7975

Article Information

vol. 11 no. 475

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 16, 2018
  • Resubmitted October 8, 2018
  • Accepted for publication December 19, 2018
  • .

Author Information

  1. Caroline B. Kurtz1,*,
  2. Yves A. Millet1,,
  3. Marja K. Puurunen1,
  4. Mylène Perreault1,
  5. Mark R. Charbonneau1,
  6. Vincent M. Isabella1,
  7. Jonathan W. Kotula1,,
  8. Eugene Antipov1,
  9. Yossi Dagon1,
  10. William S. Denney2,
  11. David A. Wagner3,
  12. Kip A. West1,
  13. Andrew J. Degar4,
  14. Aoife M. Brennan1 and
  15. Paul F. Miller1
  1. 1Synlogic Inc., 301 Binney Street, Cambridge, MA 02142, USA.
  2. 2Human Predictions LLC, 649 Massachusetts Avenue Suite 6, Cambridge, MA 02139, USA.
  3. 3Metabolic Solutions Inc., 460 Amherst Street, Nashua, NH 03063, USA.
  4. 4Diversigen Inc., 1 Baylor Plaza, Houston, TX 77030, USA.
  1. *Corresponding author. Email: caroline{at}synlogictx.com
  • Present address: Kaleido Biosciences, 65 Hayden Avenue, Lexington, MA 02421, USA.

  • Present address: Caribou Biosciences, 2929 7th Street, Suite 105, Berkeley, CA 94710, USA.

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