Research ArticleRetinal Disease

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

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Science Translational Medicine  16 Jan 2019:
Vol. 11, Issue 475, eaat5580
DOI: 10.1126/scitranslmed.aat5580

Article Information

vol. 11 no. 475

PubMed: 
Print ISSN: 
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History: 
  • Received for publication March 13, 2018
  • Resubmitted October 14, 2018
  • Accepted for publication December 18, 2018

Author Information

  1. Ruchi Sharma1,*,
  2. Vladimir Khristov2,*,
  3. Aaron Rising2,*,
  4. Balendu Shekhar Jha1,
  5. Roba Dejene1,
  6. Nathan Hotaling1,
  7. Yichao Li3,
  8. Jonathan Stoddard4,
  9. Casey Stankewicz5,
  10. Qin Wan2,
  11. Connie Zhang2,
  12. Mercedes Maria Campos6,
  13. Kiyoharu J. Miyagishima2,
  14. David McGaughey7,
  15. Rafael Villasmil8,
  16. Mary Mattapallil9,
  17. Boris Stanzel10,
  18. Haohua Qian3,
  19. Wai Wong11,
  20. Lucas Chase5,
  21. Steve Charles12,
  22. Trevor McGill4,
  23. Sheldon Miller2,
  24. Arvydas Maminishkis2,
  25. Juan Amaral13 and
  26. Kapil Bharti1,
  1. 1Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  2. 2Section on Epithelial and Retinal Physiology and Disease, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  3. 3Visual Function Core, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  4. 4Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
  5. 5Cellular Dynamics International Inc. (a FUJIFILM company), Madison, WI 53711, USA.
  6. 6Histology Core, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  7. 7Ophthalmic Genetics and Visual Functional Branch, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  8. 8Flow Cytometry Core, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  9. 9Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  10. 10Macula Center Saar, Sulzbach Knappschaft Eye Clinic, Sulzbach/Saar 66280, Germany.
  11. 11Unit on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  12. 12Charles Retina Institute, Germantown, TN 38138, USA.
  13. 13Office of Scientific Director, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  1. Corresponding author. Email: Kapilbharti{at}nei.nih.gov
  • * These authors contributed equally to this work as first authors.

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Jan 201949471221745
Feb 2019977318292
Mar 2019677210183
Apr 2019468113133
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Jun 201945611174
Jul 20191743827