Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus

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Science Translational Medicine  16 Jan 2019:
Vol. 11, Issue 475, eaat0882
DOI: 10.1126/scitranslmed.aat0882

Circumventing Staphylococcus aureus subversion

Staphylococcus aureus subverts the host immune system with various mechanisms, including the cytolytic leukocidins. Chan et al. modified a protein scaffold to generate centryins, which bind S. aureus leukocidins in vitro and can protect human cells from leukocidin-mediated lysis. Further modification to extend centryin half-life in circulation led to antibacterial protection in various mouse models. These centryins could one day be used to prevent or possibly treat S. aureus infections in people.

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