Loss of HDAC3 results in nonreceptive endometrium and female infertility

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Science Translational Medicine  09 Jan 2019:
Vol. 11, Issue 474, eaaf7533
DOI: 10.1126/scitranslmed.aaf7533

Connecting the dots in endometriosis

Endometriosis is a clinical condition in which deposits of endometrium (uterine lining tissue) are found outside the uterus, resulting in chronic pain and infertility. There is no specific treatment for endometriosis, and surgical interventions produce only transient improvement. Kim et al. found that the endometrium of women with this disease is low in histone deacetylase 3 and confirmed this observation in animal models. The authors then used these models to determine the mechanism connecting the deficiency in histone deacetylase 3 to impairment of embryo implantation, explaining the observed pathology and suggesting a pathway for possible intervention.

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