09 January 2019
Vol 11, Issue 474

About The Cover

Cover image expansion

ONLINE COVER To Sleep, Perchance to Dream. The image depicts an older person sleeping. Measuring sleep with electroencephalography and imaging in the brains of cognitively normal aging individuals revealed a correlation between altered sleep patterns and Alzheimer's disease (AD) pathology (Lucey et al.). Slow wave activity during non–rapid eye movement (NREM) sleep decreased with increasing tau expression and amyloid β deposition. Time to fall asleep and time to enter REM sleep were also reduced with increasing AD pathology. These results suggest that, in some older individuals, altered sleep patterns might precede the development of symptomatic AD. [CREDIT: BARANOZDEMIR/ISTOCKPHOTO]