Contents
09 January 2019
Vol 11, Issue 474
Vol 11, Issue 474
Review
- Challenges and strategies for developing efficacious and long-lasting malaria vaccines
New knowledge and strategies are emerging to enable the development of an efficacious and long-lasting vaccine against malaria.
Research Articles
- Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease
Slow wave activity during non–rapid eye movement sleep decreases with disease progression in patients with Alzheimer’s disease.
- Opioid overdose detection using smartphones
A commodity smartphone is converted into a contactless monitor that uses active sonar to detect opioid overdose and its precursors.
- Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion
This study investigated the application of a therapeutic tumor cell–derived microparticle-based nanodelivery platform in malignant pleural effusion.
- Loss of HDAC3 results in nonreceptive endometrium and female infertility
Histone deacetylase 3 plays a critical role for early pregnancy through transcriptional regulation of COL1A1 and COL1A2 genes.
Editors' Choice
- Keep calm…and learn
Social anxiety disrupts optimal learning patterns and brain activity in threatening situations.
- Defining chronic kidney disease at the genetic level
Exome sequencing reveals the genetic complexity of chronic kidney disease.
- Interfer-ing with immunotherapy-induced autoimmunity
Inhibition of type I IFN prevents autoimmune toxicity while preserving antitumor efficacy of combined cancer vaccine and adoptive cell therapy.
Erratum
About The Cover
ONLINE COVER To Sleep, Perchance to Dream. The image depicts an older person sleeping. Measuring sleep with electroencephalography and imaging in the brains of cognitively normal aging individuals revealed a correlation between altered sleep patterns and Alzheimer's disease (AD) pathology (Lucey et al.). Slow wave activity during non–rapid eye movement (NREM) sleep decreased with increasing tau expression and amyloid β deposition. Time to fall asleep and time to enter REM sleep were also reduced with increasing AD pathology. These results suggest that, in some older individuals, altered sleep patterns might precede the development of symptomatic AD. [CREDIT: BARANOZDEMIR/ISTOCKPHOTO]