Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

Wei Yang; Nicole M. Warrington; Sara J. Taylor; Paula Whitmire; Eduardo Carrasco; Kyle W. Singleton; Ningying Wu; Justin D. Lathia; Michael E. Berens; Albert H. Kim; Jill S. Barnholtz-Sloan; Kristin R. Swanson; Jingqin Luo; Joshua B. Rubin

doi:10.1126/scitranslmed.aao5253

Research ArticleCancer

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

Wei Yang¹,
Nicole M. Warrington²,
Sara J. Taylor²,
Paula Whitmire³,
Eduardo Carrasco³,
Kyle W. Singleton³,
Ningying Wu⁴,⁵,
Justin D. Lathia⁶,
Michael E. Berens ⁷,
Albert H. Kim ⁸,⁹,
Jill S. Barnholtz-Sloan¹⁰,
Kristin R. Swanson ³,⁵,
Jingqin Luo⁴,¹¹,*,† and
Joshua B. Rubin ²,⁹,*,†

¹Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
²Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
³Precision Neurotherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, AZ 85054, USA.
⁴Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.
⁵School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85281, USA.
⁶Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland OH, 44195, USA.
⁷Cancer and Cell Biology Division, TGen, Phoenix, AZ 85004, USA.
⁸Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
⁹Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
¹⁰Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
¹¹Siteman Cancer Center Biostatistics Core, Washington University School of Medicine, St. Louis, MO 63110, USA.

↵*Corresponding author. Email: rubin_j{at}wustl.edu (J.B.R.); jingqinluo{at}wustl.edu (J.L.)

↵† These authors contributed equally to this work.

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Science Translational Medicine 02 Jan 2019:
Vol. 11, Issue 473, eaao5253
DOI: 10.1126/scitranslmed.aao5253

Wei Yang

1Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Nicole M. Warrington

2Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Sara J. Taylor

2Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Paula Whitmire

3Precision Neurotherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, AZ 85054, USA.

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Eduardo Carrasco

3Precision Neurotherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, AZ 85054, USA.

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Kyle W. Singleton

3Precision Neurotherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, AZ 85054, USA.

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Ningying Wu

4Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.

5School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85281, USA.

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Justin D. Lathia

6Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland OH, 44195, USA.

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Michael E. Berens

7Cancer and Cell Biology Division, TGen, Phoenix, AZ 85004, USA.

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Albert H. Kim

8Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

9Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Jill S. Barnholtz-Sloan

10Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

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Kristin R. Swanson

3Precision Neurotherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, AZ 85054, USA.

5School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85281, USA.

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Jingqin Luo

4Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.

11Siteman Cancer Center Biostatistics Core, Washington University School of Medicine, St. Louis, MO 63110, USA.

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For correspondence: rubin_j@wustl.edu jingqinluo@wustl.edu

Joshua B. Rubin

2Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

9Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.

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For correspondence: rubin_j@wustl.edu jingqinluo@wustl.edu

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Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

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