Research ArticleCancer

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

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Science Translational Medicine  02 Jan 2019:
Vol. 11, Issue 473, eaao5253
DOI: 10.1126/scitranslmed.aao5253

Brain tumors’ battle of the sexes

In recent years, there has been increasing interest in personalized medicine for cancer, considering the unique biology of each tumor and patient to optimize therapeutic approaches. Sex differences play a role in patient outcomes, and Yang et al. determined that in the case of the brain tumor glioblastoma, these go beyond hormonal influences and appear to be intrinsic to the tumor cells themselves. The authors found that the sex of the patient correlates not only with prognosis but also with responses to different treatments, suggesting that it may be an important factor to consider when optimizing the therapeutic regimen for each patient.

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