Research ArticleMalaria
A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir
- View ORCID ProfileDingyin Tao1,2,*,†,
- View ORCID ProfileBrent McGill1,2,†,
- View ORCID ProfileTimothy Hamerly1,2,3,†,
- Tamaki Kobayashi2,4,‡,
- Prachi Khare3,‡,
- View ORCID ProfileAmanda Dziedzic1,‡,
- View ORCID ProfileTomasz Leski5,
- View ORCID ProfileAndrew Holtz6,
- Bruce Shull7,
- View ORCID ProfileAnne E. Jedlicka1,
- View ORCID ProfileAndrew Walzer7,
- View ORCID ProfilePaul D. Slowey8,
- Christopher C. Slowey8,
- Sandrine E. Nsango9,10,
- David A. Stenger5,
- View ORCID ProfileMike Chaponda11,
- Modest Mulenga11,
- View ORCID ProfileKathryn H. Jacobsen12,
- David J. Sullivan1,
- View ORCID ProfileSadie J. Ryan13,
- Rashid Ansumana14,
- William J. Moss2,4,
- View ORCID ProfileIsabelle Morlais9 and
- View ORCID ProfileRhoel R. Dinglasan1,2,3,§
- 1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- 2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
- 3Emerging Pathogens Institute and Department of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.
- 4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- 5United States Naval Research Laboratory (NRL), Center for Biomolecular Science and Engineering, Washington, DC 20375, USA.
- 6College of Science, George Mason University, Fairfax, VA 22030, USA.
- 7Thermo Fisher Scientific, Fremont, CA 94538, USA.
- 8Oasis Diagnostics, Vancouver, WA 98686, USA.
- 9Laboratoire de Recherche sur le Paludisme, Institut de Recherche pour le Développement–Organisation de Coordination et de Coopération pour la Lutte Contre les Grandes Endémies en Afrique Centrale (IRD-OCEAC), Yaoundé, Cameroon.
- 10Faculty of Medicine and Pharmaceutical Sciences, University of Douala, PO Box 2701, Douala, Cameroon.
- 11Tropical Disease Research Centre, Ndola, Zambia.
- 12College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA.
- 13Emerging Pathogens Institute and Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.
- 14Mercy Hospital Research Laboratory, Kulanda Town, Bo, Sierra Leone.
- ↵§Corresponding author. Email: rdinglasan{at}epi.ufl.edu
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Science Translational Medicine 02 Jan 2019:
Vol. 11, Issue 473, eaan4479
DOI: 10.1126/scitranslmed.aan4479
Vol. 11, Issue 473, eaan4479
DOI: 10.1126/scitranslmed.aan4479
Dingyin Tao
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
Brent McGill
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
Timothy Hamerly
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
3Emerging Pathogens Institute and Department of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.
Tamaki Kobayashi
2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Prachi Khare
3Emerging Pathogens Institute and Department of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.
Amanda Dziedzic
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Tomasz Leski
5United States Naval Research Laboratory (NRL), Center for Biomolecular Science and Engineering, Washington, DC 20375, USA.
Andrew Holtz
6College of Science, George Mason University, Fairfax, VA 22030, USA.
Bruce Shull
7Thermo Fisher Scientific, Fremont, CA 94538, USA.
Anne E. Jedlicka
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Andrew Walzer
7Thermo Fisher Scientific, Fremont, CA 94538, USA.
Paul D. Slowey
8Oasis Diagnostics, Vancouver, WA 98686, USA.
Christopher C. Slowey
8Oasis Diagnostics, Vancouver, WA 98686, USA.
Sandrine E. Nsango
9Laboratoire de Recherche sur le Paludisme, Institut de Recherche pour le Développement–Organisation de Coordination et de Coopération pour la Lutte Contre les Grandes Endémies en Afrique Centrale (IRD-OCEAC), Yaoundé, Cameroon.
10Faculty of Medicine and Pharmaceutical Sciences, University of Douala, PO Box 2701, Douala, Cameroon.
David A. Stenger
5United States Naval Research Laboratory (NRL), Center for Biomolecular Science and Engineering, Washington, DC 20375, USA.
Mike Chaponda
11Tropical Disease Research Centre, Ndola, Zambia.
Modest Mulenga
11Tropical Disease Research Centre, Ndola, Zambia.
Kathryn H. Jacobsen
12College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA.
David J. Sullivan
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Sadie J. Ryan
13Emerging Pathogens Institute and Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.
Rashid Ansumana
14Mercy Hospital Research Laboratory, Kulanda Town, Bo, Sierra Leone.
William J. Moss
2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Isabelle Morlais
9Laboratoire de Recherche sur le Paludisme, Institut de Recherche pour le Développement–Organisation de Coordination et de Coopération pour la Lutte Contre les Grandes Endémies en Afrique Centrale (IRD-OCEAC), Yaoundé, Cameroon.
Rhoel R. Dinglasan
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
2Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
3Emerging Pathogens Institute and Department of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.
