Contents
02 January 2019
Vol 11, Issue 473
Vol 11, Issue 473
Research Articles
- Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents
A catalytic nanoscavenger with long blood residence time provides long-term prophylactic protection against nerve agents in animal models.
- A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir
A noninvasive malaria rapid test assesses subclinical carriage of Plasmodium falciparum (human malaria) parasites at the point of need.
- Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data
Male and female glioblastomas are biologically distinct, and improving outcomes may require sex-specific approaches to treatment.
- Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
A cellular thermal shift assay (CETSA) protocol identifies and resolves antimalarial drug targets in P. falciparum.
Editors' Choice
- “Yabba-GABA-Doo”: Meet the microbiome
The microbiome is an important regulator of GABA, which has implications for major depressive disorder.
- Protein silencing to stop a “silent killer”
Delivery of a single dose of siRNA to the placenta silences proteins and may help prevent preeclampsia.
- It’s all in the wrist
Motor patterns measured by wrist actigraphy differentiate epileptic seizures from nonepileptic spells.
About The Cover
ONLINE COVER Up and Away. Pictured here is a plane spraying crops with a pesticide. Organophosphates (OP) are neurotoxic compounds found in pesticides and chemical warfare agents that act by irreversibly inhibiting acetylcholinesterase in neuromuscular synapses. Exposure to high OP doses causes neuromuscular paralysis and death by asphyxiation. Zhang et al. developed a nanoparticle-based OP bioscavenger (nanoscavenger) that provided long-term prophylactic protection against OP poisoning in rodents. A single administration protected the animals for one week after repeated exposure to a warfare agent or pesticide. This suggests that nanoscavengers could help to protect against the toxic effects of OP poisoning in people at risk of exposure. [CREDIT: BRIAN BROWN/ISTOCKPHOTO]