Research ArticleGUT MICROBIOTA

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

See allHide authors and affiliations

Science Translational Medicine  19 Dec 2018:
Vol. 10, Issue 472, eaap8914
DOI: 10.1126/scitranslmed.aap8914

Distinguishing two similar gut disorders

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are two of the most common diseases of the gastrointestinal tract. In new work, Vich Vila and colleagues have characterized the gut microbiota composition of both disorders using shotgun metagenomic sequencing of stool samples from 1792 individuals. Analyses involving bacterial taxonomy, metabolic functions, antibiotic resistance genes, virulence factors, and bacterial growth rates showed key differences between these two gut disorders. On the basis of gut microbiota composition differences, patients with IBD could be distinguished from those with IBS.

View Full Text

Stay Connected to Science Translational Medicine