19 December 2018
Vol 10, Issue 472

About The Cover

Cover image expansion

ONLINE COVER Illuminating the Brain. The image of a neon brain represents individual genetic variability that may contribute to psychiatric diseases such as bipolar disease or schizophrenia (represented by the dim segments). Such genetic variability is reported in a collection of papers from the PsychENCODE Consortium published in Science Translational Medicine (Chen et al., Meng et al.), Science, and Science Advances. Chen et al. report that the transcription factor POU3F2 is a core regulator of a gene coexpression network associated with these disorders. Meanwhile, Meng et al. report that the lncRNA DGCR5 regulates expression of several genes associated with schizophrenia. [CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]