Contents
19 December 2018
Vol 10, Issue 472
Vol 10, Issue 472
Research Articles
- The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders
POU3F2 regulates expression of key genes in postmortem brain tissue from patients with schizophrenia or bipolar disorder.
- The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes
The long noncoding RNA DGCR5 in the 22q11.2 deletion may regulate expression of certain protein-coding genes that are associated with schizophrenia.
- Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Differences in gut microbiota composition and function were observed between patients with inflammatory bowel disease or irritable bowel syndrome.
- Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Antibody antagonists of the insulinotropic receptor GIPR prevent weight gain in obese animal models, and the effect is enhanced by GLP-1R agonists.
Technical Comment
- Comment on “The impact of past vaccination coverage and immunity on pertussis resurgence”
A recently published study does not accurately model the resurgence of pertussis observed in the United States due to the lack of acellular pertussis vaccine recipients in the study cohort.
Technical Response
- Response to Comment on “The impact of past vaccination coverage and immunity on pertussis resurgence”
We present new evidence that the immunity conferred against pertussis by the DTaP acellular vaccine wanes more slowly than widely believed.
Editors' Choice
- After the CRISPR-Cas9 cut: Predicting generated mutations
Analysis of synthetic guide RNA targets yields prediction algorithms for expected mutations following genome editing.
- A lncRNA that regulates cholesterol homeostasis
The primate-specific long noncoding RNA CHROME regulates cholesterol metabolism through its interaction with specific microRNAs.
- Early-life host-microbial cross-talk in the lung
Early-life bacterial colonization patterns of the lower airways are an important determinant of the priming of the immune system.
About The Cover
ONLINE COVER Illuminating the Brain. The image of a neon brain represents individual genetic variability that may contribute to psychiatric diseases such as bipolar disease or schizophrenia (represented by the dim segments). Such genetic variability is reported in a collection of papers from the PsychENCODE Consortium published in Science Translational Medicine (Chen et al., Meng et al.), Science, and Science Advances. Chen et al. report that the transcription factor POU3F2 is a core regulator of a gene coexpression network associated with these disorders. Meanwhile, Meng et al. report that the lncRNA DGCR5 regulates expression of several genes associated with schizophrenia. [CREDIT: V. ALTOUNIAN/SCIENCE TRANSLATIONAL MEDICINE]