A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases

David Sebba; Alexander G. Lastovich; Melody Kuroda; Eric Fallows; Joshua Johnson; Ambroise Ahouidi; Anna N. Honko; Henry Fu; Rex Nielson; Erin Carruthers; Cyrille Diédhiou; Doré Ahmadou; Barré Soropogui; John Ruedas; Kristen Peters; Miroslaw Bartkowiak; N’Faly Magassouba; Souleymane Mboup; Yanis Ben Amor; John H. Connor; Kristin Weidemaier

doi:10.1126/scitranslmed.aat0944

Research ArticleDiagnostics

A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases

David Sebba¹,*,
Alexander G. Lastovich¹,*,
Melody Kuroda¹,
Eric Fallows¹,
Joshua Johnson²,
Ambroise Ahouidi³,⁴,
Anna N. Honko²,
Henry Fu¹,
Rex Nielson¹,
Erin Carruthers¹,
Cyrille Diédhiou³,
Doré Ahmadou⁵,
Barré Soropogui⁵,
John Ruedas⁶,
Kristen Peters⁶,
Miroslaw Bartkowiak¹,
N’Faly Magassouba⁵,
Souleymane Mboup³,⁴,
Yanis Ben Amor⁷,
John H. Connor⁶,† and
Kristin Weidemaier ¹,†

¹Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.
²Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA.
³Laboratory of Bacteriology and Virology, Le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
⁴Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formations (IRESSEF), Diamniadio, BP 7325, Dakar, Senegal.
⁵Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.
⁶Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.
⁷Center for Sustainable Development, Earth Institute at Columbia University, 475 Riverside Drive, Suite 1040, New York, NY 10115, USA.

↵†Corresponding author. Email: kristin.weidemaier{at}bd.com (K.W.); jhconnor{at}bu.edu (J.H.C.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 12 Dec 2018:
Vol. 10, Issue 471, eaat0944
DOI: 10.1126/scitranslmed.aat0944

David Sebba

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Alexander G. Lastovich

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Melody Kuroda

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Eric Fallows

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Joshua Johnson

Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA.

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Ambroise Ahouidi

Laboratory of Bacteriology and Virology, Le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formations (IRESSEF), Diamniadio, BP 7325, Dakar, Senegal.

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Anna N. Honko

Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA.

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Henry Fu

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Rex Nielson

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Erin Carruthers

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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Cyrille Diédhiou

Laboratory of Bacteriology and Virology, Le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.

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Doré Ahmadou

Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.

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Barré Soropogui

Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.

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John Ruedas

Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.

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Kristen Peters

Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.

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Miroslaw Bartkowiak

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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N’Faly Magassouba

Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.

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Souleymane Mboup

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Yanis Ben Amor

Center for Sustainable Development, Earth Institute at Columbia University, 475 Riverside Drive, Suite 1040, New York, NY 10115, USA.

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John H. Connor

Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.

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For correspondence: kristin.weidemaier@bd.comjhconnor@bu.edu

Kristin Weidemaier

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

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For correspondence: kristin.weidemaier@bd.comjhconnor@bu.edu

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