A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases

David Sebba; Alexander G. Lastovich; Melody Kuroda; Eric Fallows; Joshua Johnson; Ambroise Ahouidi; Anna N. Honko; Henry Fu; Rex Nielson; Erin Carruthers; Cyrille Diédhiou; Doré Ahmadou; Barré Soropogui; John Ruedas; Kristen Peters; Miroslaw Bartkowiak; N’Faly Magassouba; Souleymane Mboup; Yanis Ben Amor; John H. Connor; Kristin Weidemaier

doi:10.1126/scitranslmed.aat0944

Research ArticleDiagnostics

A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases

David Sebba¹,*,
Alexander G. Lastovich¹,*,
Melody Kuroda¹,
Eric Fallows¹,
Joshua Johnson²,
Ambroise Ahouidi³,⁴,
Anna N. Honko²,
Henry Fu¹,
Rex Nielson¹,
Erin Carruthers¹,
Cyrille Diédhiou³,
Doré Ahmadou⁵,
Barré Soropogui⁵,
John Ruedas⁶,
Kristen Peters⁶,
Miroslaw Bartkowiak¹,
N’Faly Magassouba⁵,
Souleymane Mboup³,⁴,
Yanis Ben Amor⁷,
John H. Connor⁶,† and
Kristin Weidemaier ¹,†

¹Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.
²Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA.
³Laboratory of Bacteriology and Virology, Le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
⁴Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formations (IRESSEF), Diamniadio, BP 7325, Dakar, Senegal.
⁵Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.
⁶Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.
⁷Center for Sustainable Development, Earth Institute at Columbia University, 475 Riverside Drive, Suite 1040, New York, NY 10115, USA.

↵†Corresponding author. Email: kristin.weidemaier{at}bd.com (K.W.); jhconnor{at}bu.edu (J.H.C.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 12 Dec 2018:
Vol. 10, Issue 471, eaat0944
DOI: 10.1126/scitranslmed.aat0944

David Sebba

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for David Sebba

Alexander G. Lastovich

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alexander G. Lastovich

Melody Kuroda

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Melody Kuroda

Eric Fallows

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Eric Fallows

Joshua Johnson

Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joshua Johnson

Ambroise Ahouidi

Laboratory of Bacteriology and Virology, Le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formations (IRESSEF), Diamniadio, BP 7325, Dakar, Senegal.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anna N. Honko

Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anna N. Honko

Henry Fu

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Henry Fu

Rex Nielson

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Erin Carruthers

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Cyrille Diédhiou

Laboratory of Bacteriology and Virology, Le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Doré Ahmadou

Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Barré Soropogui

Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John Ruedas

Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kristen Peters

Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kristen Peters

Miroslaw Bartkowiak

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Miroslaw Bartkowiak

N’Faly Magassouba

Hemorrhagic Fever Laboratory, Université Gamal Abdel Nasser de Conakry, BP 5680, Conakry, Guinea.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Souleymane Mboup

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yanis Ben Amor

Center for Sustainable Development, Earth Institute at Columbia University, 475 Riverside Drive, Suite 1040, New York, NY 10115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yanis Ben Amor

John H. Connor

Department of Microbiology and National Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albany Street, Boston, MA 02118, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for John H. Connor
For correspondence: kristin.weidemaier@bd.com jhconnor@bu.edu

Kristin Weidemaier

Becton, Dickinson and Company, 21 Davis Drive, Research Triangle Park, NC 27709, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kristin Weidemaier
For correspondence: kristin.weidemaier@bd.com jhconnor@bu.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view PDF

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become a AAAS member
Activate account
Add journals
Account help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View Full Text

A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases

Log in to view PDF

Log in through your institution

Log in through your institution

More options

Science Translational Medicine

Article Tools