05 December 2018
Vol 10, Issue 470

About The Cover

Cover image expansion

ONLINE COVER Lean on Me. The photograph depicts an 86-year old farmer under one of the oldest productive olive trees in Sardinia. Analyzing memory B cell repertoires of the healthy elderly enabled Maier et al. to develop human antibodies targeting misfolded forms of superoxide dismutase 1 (SOD1). This enzyme is mutated in an inherited form of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In animal models of ALS, antibody treatment delayed the onset of motor impairments, extended survival, and reduced the accumulation of SOD1 aggregates and degeneration of neurons. [CREDIT: PHOTOGRAPH BY KARSTEN THORMAEHLEN FROM THE EXHIBITION "PIONEERS OF THE FUTURE" AT THE UNIVERSITY OF ZURICH]