Research ArticleGraft-Versus-Host Disease

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells

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Science Translational Medicine  28 Nov 2018:
Vol. 10, Issue 469, eaat8410
DOI: 10.1126/scitranslmed.aat8410

Article Information

vol. 10 no. 469

PubMed: 
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History: 
  • Received for publication April 10, 2018
  • Resubmitted July 27, 2018
  • Accepted for publication October 29, 2018
  • .

Author Information

  1. Sonia Tugues1,*,,
  2. Ana Amorim1,*,
  3. Sabine Spath1,*,,
  4. Guillaume Martin-Blondel1,2,
  5. Bettina Schreiner1,3,
  6. Donatella De Feo1,
  7. Mirjam Lutz1,
  8. Franco Guscetti4,
  9. Petya Apostolova5,
  10. Claudia Haftmann1,
  11. Peter Hasselblatt6,
  12. Nicolas G. Núñez1,
  13. Michael O. Hottiger7,
  14. Maries van den Broek1,
  15. Markus G. Manz8,
  16. Robert Zeiser5 and
  17. Burkhard Becher1,
  1. 1Institute of Experimental Immunology,University of Zurich, CH-8057 Zurich, Switzerland.
  2. 2INSERM U1043-CNRS UMR 5282, Physiopathology Center of Toulouse-Purpan, Toulouse, France.
  3. 3Neurology Clinic, University Hospital of Zurich, 8091 Zurich, Switzerland.
  4. 4Institute of Veterinary Pathology, University of Zurich, 8057 Zurich, Switzerland.
  5. 5Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, 79110 Freiburg, Germany.
  6. 6Department of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Freiburg University Medical Center, 79110 Freiburg, Germany.
  7. 7Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
  8. 8Department of Hematology and Oncology, University and University Hospital 8091 Zurich, Switzerland.
  1. Corresponding author. Email: tugues{at}immunology.uzh.ch (S.T.); becher{at}immunology.uzh.ch (B.B.)
  • * These authors contributed equally to this work.

  • Present address: Benaroya Research Institute, Seattle, WA 98101, USA.

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