Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Jonathan M. Tsai; Rahul Sinha; Jun Seita; Nathaniel Fernhoff; Simon Christ; Tim Koopmans; Geoffrey W. Krampitz; Kelly M. McKenna; Liujing Xing; Michael Sandholzer; Jennifer Horatia Sales; Maia Shoham; Melissa McCracken; Lydia-Marie Joubert; Sydney R. Gordon; Nicolas Poux; Gerlinde Wernig; Jeffrey A. Norton; Irving L. Weissman; Yuval Rinkevich

doi:10.1126/scitranslmed.aan6735

Research ArticleSURGICAL ADHESIONS

Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Jonathan M. Tsai ¹,²,
Rahul Sinha¹,
Jun Seita³,
Nathaniel Fernhoff ¹,
Simon Christ⁴,
Tim Koopmans⁴,
Geoffrey W. Krampitz¹,⁵,
Kelly M. McKenna¹,
Liujing Xing²,
Michael Sandholzer⁴,
Jennifer Horatia Sales⁴,
Maia Shoham¹,
Melissa McCracken¹,
Lydia-Marie Joubert⁶,
Sydney R. Gordon¹,
Nicolas Poux¹,
Gerlinde Wernig⁷,
Jeffrey A. Norton⁵,
Irving L. Weissman ¹,²,⁷,⁸,*,† and
Yuval Rinkevich ⁴,*,†

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
²Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
³AI based Healthcare and Medical Data Analysis Standardization Unit, Medical Sciences Innovation Hub Program, RIKEN, Tokyo 103-0027, Japan.
⁴Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
⁵Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁶Cell Sciences Imaging Facility, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁸Ludwig Center for Cancer Stem Cell Biology and Medicine at Stanford University, Stanford, CA 94305, USA.

↵*Corresponding author. Email: yuval.rinkevich{at}helmholtz-muenchen.de (Y.R.); irv{at}stanford.edu (I.L.W.)

↵† These authors contributed equally to this work as co-senior authors.

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Science Translational Medicine 28 Nov 2018:
Vol. 10, Issue 469, eaan6735
DOI: 10.1126/scitranslmed.aan6735

Jonathan M. Tsai

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Rahul Sinha

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Jun Seita

AI based Healthcare and Medical Data Analysis Standardization Unit, Medical Sciences Innovation Hub Program, RIKEN, Tokyo 103-0027, Japan.

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Nathaniel Fernhoff

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Simon Christ

Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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Tim Koopmans

Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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Geoffrey W. Krampitz

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Kelly M. McKenna

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Liujing Xing

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Michael Sandholzer

Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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Jennifer Horatia Sales

Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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Maia Shoham

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Melissa McCracken

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Lydia-Marie Joubert

Cell Sciences Imaging Facility, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Sydney R. Gordon

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Nicolas Poux

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Gerlinde Wernig

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Jeffrey A. Norton

Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Irving L. Weissman

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.Ludwig Center for Cancer Stem Cell Biology and Medicine at Stanford University, Stanford, CA 94305, USA.

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For correspondence: yuval.rinkevich@helmholtz-muenchen.de irv@stanford.edu

Yuval Rinkevich

Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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For correspondence: yuval.rinkevich@helmholtz-muenchen.de irv@stanford.edu

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Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

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