Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Jonathan M. Tsai; Rahul Sinha; Jun Seita; Nathaniel Fernhoff; Simon Christ; Tim Koopmans; Geoffrey W. Krampitz; Kelly M. McKenna; Liujing Xing; Michael Sandholzer; Jennifer Horatia Sales; Maia Shoham; Melissa McCracken; Lydia-Marie Joubert; Sydney R. Gordon; Nicolas Poux; Gerlinde Wernig; Jeffrey A. Norton; Irving L. Weissman; Yuval Rinkevich

doi:10.1126/scitranslmed.aan6735

Research ArticleSURGICAL ADHESIONS

Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

View ORCID ProfileJonathan M. Tsai ¹,²,
View ORCID ProfileRahul Sinha¹,
View ORCID ProfileJun Seita³,
Nathaniel Fernhoff ¹,
View ORCID ProfileSimon Christ⁴,
View ORCID ProfileTim Koopmans⁴,
View ORCID ProfileGeoffrey W. Krampitz¹,⁵,
Kelly M. McKenna¹,
Liujing Xing²,
View ORCID ProfileMichael Sandholzer⁴,
Jennifer Horatia Sales⁴,
Maia Shoham¹,
Melissa McCracken¹,
View ORCID ProfileLydia-Marie Joubert⁶,
Sydney R. Gordon¹,
Nicolas Poux¹,
View ORCID ProfileGerlinde Wernig⁷,
Jeffrey A. Norton⁵,
View ORCID ProfileIrving L. Weissman ¹,²,⁷,⁸,*,† and
View ORCID ProfileYuval Rinkevich ⁴,*,†

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
²Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
³AI based Healthcare and Medical Data Analysis Standardization Unit, Medical Sciences Innovation Hub Program, RIKEN, Tokyo 103-0027, Japan.
⁴Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
⁵Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁶Cell Sciences Imaging Facility, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁸Ludwig Center for Cancer Stem Cell Biology and Medicine at Stanford University, Stanford, CA 94305, USA.

↵*Corresponding author. Email: yuval.rinkevich{at}helmholtz-muenchen.de (Y.R.); irv{at}stanford.edu (I.L.W.)

↵† These authors contributed equally to this work as co-senior authors.

See allHide authors and affiliations

Science Translational Medicine 28 Nov 2018:
Vol. 10, Issue 469, eaan6735
DOI: 10.1126/scitranslmed.aan6735

Jonathan M. Tsai

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

2Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jonathan M. Tsai

Rahul Sinha

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rahul Sinha

Jun Seita

3AI based Healthcare and Medical Data Analysis Standardization Unit, Medical Sciences Innovation Hub Program, RIKEN, Tokyo 103-0027, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jun Seita

Nathaniel Fernhoff

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Simon Christ

4Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Simon Christ

Tim Koopmans

4Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tim Koopmans

Geoffrey W. Krampitz

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

5Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Geoffrey W. Krampitz

Kelly M. McKenna

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Liujing Xing

2Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael Sandholzer

4Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Michael Sandholzer

Jennifer Horatia Sales

4Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maia Shoham

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Melissa McCracken

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lydia-Marie Joubert

6Cell Sciences Imaging Facility, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lydia-Marie Joubert

Sydney R. Gordon

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nicolas Poux

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gerlinde Wernig

7Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gerlinde Wernig

Jeffrey A. Norton

5Department of General Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Irving L. Weissman

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

2Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

7Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

8Ludwig Center for Cancer Stem Cell Biology and Medicine at Stanford University, Stanford, CA 94305, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Irving L. Weissman
For correspondence: yuval.rinkevich@helmholtz-muenchen.de irv@stanford.edu

Yuval Rinkevich

4Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yuval Rinkevich
For correspondence: yuval.rinkevich@helmholtz-muenchen.de irv@stanford.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools