28 November 2018
Vol 10, Issue 469

About The Cover

Cover image expansion

ONLINE COVER Surgery's Sticking Points. Injury of the mesothelium during abdominal surgery in mice results in formation of fibrous tissue called adhesions, revealed here in an immunofluorescence image. Adhesion formation following surgery leads to serious complications in many patients at an annual cost of $1 billion in the United States. The cover image shows adhesions between the mouse liver, peritoneal wall, and intestine visualized using fluorophore-tagged antibodies against mesothelial cell markers such as mesothelin (red). Surgically-induced adhesions in mice can be resolved using antibodies targeting mesothelin and can be prevented using inhibitors of HIF1α (Tsai et al.). [CREDIT: TSAI ET AL./SCIENCE TRANSLATIONAL MEDICINE]