Contents
28 November 2018
Vol 10, Issue 469
Vol 10, Issue 469
Focus
- Catering to chondrocytes
An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al., this issue).
Research Articles
- Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis
A charged molecular carrier enables sustained growth factor delivery to cartilage, demonstrating therapeutic benefit in a rat model of osteoarthritis.
- Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers
Surgical adhesions in mice derived from hypoxia-responsive mesothelial cells can be targeted with anti-mesothelial antibodies.
- Gene therapy reduces Parkinson’s disease symptoms by reorganizing functional brain connectivity
A polysynaptic brain circuit in patients with Parkinson’s disease treated with AAV2-GAD gene therapy correlates with improvement in motor symptoms.
- Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells
Myeloid cells mediate GvHD immunopathology, whereas GvL relies on T cell cytotoxicity.
Editors' Choice
- DNA folding for renal rescue
DNA origami nanostructures offer an alternative therapeutic for kidney targeting and treatment of acute kidney injury in mice.
- Decoding the mood network
Machine learning and intracranial electroencephalography recordings reveal a circuit mechanism encoding mood state fluctuations over time.
- The two immune sides of obesity
Obesity promotes PD-1–mediated T cell dysfunction but also improves tumor response to immune checkpoint blockade.
Erratum
About The Cover
ONLINE COVER Surgery's Sticking Points. Injury of the mesothelium during abdominal surgery in mice results in formation of fibrous tissue called adhesions, revealed here in an immunofluorescence image. Adhesion formation following surgery leads to serious complications in many patients at an annual cost of $1 billion in the United States. The cover image shows adhesions between the mouse liver, peritoneal wall, and intestine visualized using fluorophore-tagged antibodies against mesothelial cell markers such as mesothelin (red). Surgically-induced adhesions in mice can be resolved using antibodies targeting mesothelin and can be prevented using inhibitors of HIF1α (Tsai et al.). [CREDIT: TSAI ET AL./SCIENCE TRANSLATIONAL MEDICINE]