Research ArticleLiver disease
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis
- View ORCID ProfileChangyu Zhu1,
- KyeongJin Kim1,
- Xiaobo Wang1,
- View ORCID ProfileAlberto Bartolome1,
- View ORCID ProfileMarcela Salomao2,
- View ORCID ProfilePaola Dongiovanni3,
- Marica Meroni3,
- Mark J. Graham4,
- View ORCID ProfileKatherine P. Yates5,
- View ORCID ProfileAnna Mae Diehl6,
- View ORCID ProfileRobert F. Schwabe1,
- View ORCID ProfileIra Tabas1,
- View ORCID ProfileLuca Valenti3,
- Joel E. Lavine7 and
- View ORCID ProfileUtpal B. Pajvani1,*
- 1Department of Medicine, Columbia University, New York, NY 10032, USA.
- 2Department of Pathology, Mayo Clinic, Phoenix, AZ 85054, USA.
- 3Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
- 4Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
- 5Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- 6Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
- 7Department of Pediatrics, Columbia University, New York, NY 10032, USA.
- ↵*Corresponding author. Email: up2104{at}columbia.edu
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Science Translational Medicine 21 Nov 2018:
Vol. 10, Issue 468, eaat0344
DOI: 10.1126/scitranslmed.aat0344
Vol. 10, Issue 468, eaat0344
DOI: 10.1126/scitranslmed.aat0344
Changyu Zhu
1Department of Medicine, Columbia University, New York, NY 10032, USA.
KyeongJin Kim
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Xiaobo Wang
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Alberto Bartolome
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Marcela Salomao
2Department of Pathology, Mayo Clinic, Phoenix, AZ 85054, USA.
Paola Dongiovanni
3Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
Marica Meroni
3Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
Mark J. Graham
4Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
Katherine P. Yates
5Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Anna Mae Diehl
6Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Robert F. Schwabe
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Ira Tabas
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Luca Valenti
3Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
Joel E. Lavine
7Department of Pediatrics, Columbia University, New York, NY 10032, USA.
Utpal B. Pajvani
1Department of Medicine, Columbia University, New York, NY 10032, USA.
