Research ArticleLiver disease
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis
- Changyu Zhu1,
- KyeongJin Kim1,
- Xiaobo Wang1,
- Alberto Bartolome1,
- Marcela Salomao2,
- Paola Dongiovanni3,
- Marica Meroni3,
- Mark J. Graham4,
- Katherine P. Yates5,
- Anna Mae Diehl6,
- Robert F. Schwabe1,
- Ira Tabas1,
- Luca Valenti3,
- Joel E. Lavine7 and
- Utpal B. Pajvani1,*
- 1Department of Medicine, Columbia University, New York, NY 10032, USA.
- 2Department of Pathology, Mayo Clinic, Phoenix, AZ 85054, USA.
- 3Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
- 4Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
- 5Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- 6Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
- 7Department of Pediatrics, Columbia University, New York, NY 10032, USA.
- ↵*Corresponding author. Email: up2104{at}columbia.edu
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Science Translational Medicine 21 Nov 2018:
Vol. 10, Issue 468, eaat0344
DOI: 10.1126/scitranslmed.aat0344
Vol. 10, Issue 468, eaat0344
DOI: 10.1126/scitranslmed.aat0344
Changyu Zhu
Department of Medicine, Columbia University, New York, NY 10032, USA.
KyeongJin Kim
Department of Medicine, Columbia University, New York, NY 10032, USA.
Xiaobo Wang
Department of Medicine, Columbia University, New York, NY 10032, USA.
Alberto Bartolome
Department of Medicine, Columbia University, New York, NY 10032, USA.
Marcela Salomao
Department of Pathology, Mayo Clinic, Phoenix, AZ 85054, USA.
Paola Dongiovanni
Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
Marica Meroni
Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
Mark J. Graham
Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
Katherine P. Yates
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Anna Mae Diehl
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Robert F. Schwabe
Department of Medicine, Columbia University, New York, NY 10032, USA.
Ira Tabas
Department of Medicine, Columbia University, New York, NY 10032, USA.
Luca Valenti
Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
Joel E. Lavine
Department of Pediatrics, Columbia University, New York, NY 10032, USA.
Utpal B. Pajvani
Department of Medicine, Columbia University, New York, NY 10032, USA.
