Research ArticleLiver disease

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

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Science Translational Medicine  21 Nov 2018:
Vol. 10, Issue 468, eaat0344
DOI: 10.1126/scitranslmed.aat0344

Article Information

vol. 10 no. 468

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 17, 2018
  • Resubmitted June 3, 2018
  • Accepted for publication October 31, 2018
  • .

Author Information

  1. Changyu Zhu1,
  2. KyeongJin Kim1,
  3. Xiaobo Wang1,
  4. Alberto Bartolome1,
  5. Marcela Salomao2,
  6. Paola Dongiovanni3,
  7. Marica Meroni3,
  8. Mark J. Graham4,
  9. Katherine P. Yates5,
  10. Anna Mae Diehl6,
  11. Robert F. Schwabe1,
  12. Ira Tabas1,
  13. Luca Valenti3,
  14. Joel E. Lavine7 and
  15. Utpal B. Pajvani1,*
  1. 1Department of Medicine, Columbia University, New York, NY 10032, USA.
  2. 2Department of Pathology, Mayo Clinic, Phoenix, AZ 85054, USA.
  3. 3Department of Pathophysiology and Transplantation, Università degli Studi Milano, and Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, Milan 20122, Italy.
  4. 4Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
  5. 5Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  6. 6Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  7. 7Department of Pediatrics, Columbia University, New York, NY 10032, USA.
  1. *Corresponding author. Email: up2104{at}columbia.edu

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