Research ArticleAsthma

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

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Science Translational Medicine  21 Nov 2018:
Vol. 10, Issue 468, eaao2151
DOI: 10.1126/scitranslmed.aao2151

Article Information

vol. 10 no. 468

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 27, 2017
  • Accepted for publication November 1, 2018

Author Information

  1. Hart S. Dengler1,
  2. Xiumin Wu2,
  3. Ivan Peng2,
  4. Cornelia H. Rinderknecht2,
  5. Youngsu Kwon2,
  6. Eric Suto2,
  7. Pawan Bir Kohli3,
  8. Marya Liimatta3,
  9. Kathy Barrett3,
  10. Julia Lloyd4,
  11. Gary Cain5,
  12. Mike Briggs6,
  13. Stephanie Addo6,
  14. Gary Salmon4,
  15. Savita Ubhayakar7,
  16. Gauri Deshmukh7,
  17. Sheerin K. Shahidi-Latham7,
  18. Cristine M. Quiason-Huynh7,
  19. Janet Jackman1,
  20. John Liu2,
  21. Nicholas C. Ray8,
  22. Simon C. Goodacre8,
  23. Adam Johnson3,
  24. Brent S. McKenzie2,
  25. Wyne P. Lee2,
  26. Mark Zak9,
  27. Jane R. Kenny5 and
  28. Nico Ghilardi1,*
  1. 1Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  2. 2Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  3. 3Department of Biochemical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  4. 4Department of Biology, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  5. 5Department of Safety Assessment Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  6. 6Department of Drug Metabolism and Pharmacokinetics, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  7. 7Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  8. 8Department of Chemistry, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  9. 9Department of Discovery Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  1. *Corresponding author. Email: ghilardi{at}gene.com

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