Research ArticleAsthma

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

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Science Translational Medicine  21 Nov 2018:
Vol. 10, Issue 468, eaao2151
DOI: 10.1126/scitranslmed.aao2151

Janus goes local in asthma

In asthma, swelling of the airways and increased mucus production cause breathing difficulties that can be life threatening. Although current treatments are effective in most cases, alternative strategies are needed for patients who do not respond to available drugs. Oral administration of Janus kinase 1 (JAK1) inhibitors has been shown to be effective in a mouse model of asthma; however, systemic side effects preclude their use in patients. Now, Dengler et al. have developed an inhalable JAK1 inhibitor specifically targeting JAK1 in the lung. The inhibitor exerted therapeutic effects in multiple asthma models in rodents. The results suggest that local JAK1 inhibition might be sufficient for treating asthma.

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