Research ArticleMicrobiome

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

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Science Translational Medicine  14 Nov 2018:
Vol. 10, Issue 467, eaat4271
DOI: 10.1126/scitranslmed.aat4271

Article Information

vol. 10 no. 467

PubMed: 
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History: 
  • Received for publication February 26, 2018
  • Resubmitted August 1, 2018
  • Accepted for publication October 26, 2018
  • .

Author Information

  1. Monica Bodogai1,
  2. Jennifer O’Connell2,
  3. Ki Kim1,
  4. Yoo Kim2,
  5. Kanako Moritoh1,
  6. Chen Chen1,
  7. Fedor Gusev3,
  8. Kelli Vaughan4,
  9. Natalia Shulzhenko5,
  10. Julie A. Mattison4,
  11. Catalina Lee-Chang16,
  12. Weixuan Chen7,
  13. Olga Carlson2,
  14. Kevin G. Becker8,
  15. Manoj Gurung5,
  16. Andrey Morgun9,
  17. James White10,
  18. Theresa Meade11,
  19. Kathy Perdue11,
  20. Matthias Mack12,
  21. Luigi Ferrucci13,
  22. Giorgio Trinchieri14,
  23. Rafael de Cabo13,
  24. Evgeny Rogaev3,15,16,
  25. Josephine Egan2,
  26. Jiejun Wu7 and
  27. Arya Biragyn1,*
  1. 1Immunoregulation Section, National Institute on Aging, Baltimore, MD 21224, USA.
  2. 2Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA.
  3. 3Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
  4. 4Nonhuman Primate Core Facility, National Institute on Aging, Baltimore, MD 21224, USA.
  5. 5College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
  6. 6Department of Neurological Surgery, Brain Tumor Research Institute, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  7. 7Janssen Research & Development, San Diego, CA 92121, USA.
  8. 8Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
  9. 9College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
  10. 10Resphera Biosciences, Baltimore, MD 21231, USA.
  11. 11Comparative Medicine Section, National Institute on Aging, Baltimore, MD 21224, USA.
  12. 12Department of Nephrology, Universitätsklinikum Regensburg, Regensburg 93001-93059, Germany.
  13. 13Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
  14. 14Cancer Inflammation Program, National Cancer Institute, Frederick, MD 21701, USA.
  15. 15Center for Genetics and Genetic Technologies, Faculty of Biology, Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
  16. 16Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.
  1. *Corresponding author. Email: biragyna{at}mail.nih.gov

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