14 November 2018
Vol 10, Issue 467

About The Cover

Cover image expansion

ONLINE COVER "Peak"-ing into Tissue Immune Responses. Blood sampling is a common method to assess a patient's immune status, but may not capture crucial immune reactions that occur in tissues. To examine tissue immunity, Mandal et al. designed a microneedle device, shown here with scanning electron microscopy, to assess cells within the skin. These microneedles can sample antigen-specific T cells and other cells in mouse and human skin, revealing immune responses not detectable in the peripheral circulation. The microneedles can be used repeatedly to assess immune responses over time and could lead to a better understanding of tissue-resident immunity. [CREDIT: MANDAL ET AL./SCIENCE TRANSLATIONAL MEDICINE]