Research ArticleCancer
Enhanced detection of circulating tumor DNA by fragment size analysis
- Florent Mouliere1,2,*,†,
- Dineika Chandrananda1,2,*,
- Anna M. Piskorz1,2,*,
- Elizabeth K. Moore1,2,3,*,
- James Morris1,2,
- Lise Barlebo Ahlborn4,5,
- Richard Mair1,2,6,
- Teodora Goranova1,2,
- Francesco Marass1,2,7,8,
- Katrin Heider1,2,
- Jonathan C. M. Wan1,2,
- Anna Supernat1,2,9,
- Irena Hudecova1,2,
- Ioannis Gounaris1,2,3,
- Susana Ros1,2,
- Mercedes Jimenez-Linan2,3,
- Javier Garcia-Corbacho10,
- Keval Patel1,2,
- Olga Østrup5,
- Suzanne Murphy1,2,
- Matthew D. Eldridge1,2,
- Davina Gale1,2,
- Grant D. Stewart2,3,11,
- Johanna Burge2,11,
- Wendy N. Cooper1,2,
- Michiel S. van der Heijden12,13,
- Charles E. Massie1,2,14,
- Colin Watts15,
- Pippa Corrie3,
- Simon Pacey3,14,
- Kevin M. Brindle1,2,16,
- Richard D. Baird17,
- Morten Mau-Sørensen4,
- Christine A. Parkinson1,2,3,18,19,
- Christopher G. Smith1,2,
- James D. Brenton1,2,3,18,19,‡,§ and
- Nitzan Rosenfeld1,2,‡,§
- 1Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.
- 2Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
- 3Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.
- 4Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
- 5Centre for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
- 6Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, CB2 0QQ Cambridge, UK.
- 7Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.
- 8Swiss Institute of Bioinformatics, 4058 Basel, Switzerland.
- 9Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-211 Gdańsk, Poland.
- 10Clinical Trials Unit, Clinic Institute of Haematological and Oncological Diseases, Hospital Clinic de Barcelona, 170 08036 Barcelona, Spain.
- 11Academic Urology Group, Department of Surgery, University of Cambridge, CB2 0QQ Cambridge, UK.
- 12Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
- 13Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
- 14Department of Oncology, University of Cambridge, CB2 0XZ Cambridge, UK.
- 15Institute of Cancer Genomics Science, University of Birmingham, B15 2TT Birmingham, UK.
- 16Department of Biochemistry, University of Cambridge, CB2 1QW Cambridge, UK.
- 17Early Phase Clinical Trials and Breast Cancer Research Teams, Cancer Research UK Cambridge Centre, CB2 0QQ Cambridge, UK.
- 18Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, CB2 0XZ Cambridge, UK.
- 19NIHR Cambridge Biomedical Research Centre, CB2 0QQ Cambridge, UK.
- ↵§Corresponding author. Email: james.brenton{at}cruk.cam.ac.uk (J.D.B.); nitzan.rosenfeld{at}cruk.cam.ac.uk (N.R.)
↵* These authors contributed equally to this work as co-first authors.
↵† Present address: Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV Amsterdam, Netherlands.
↵‡ These authors contributed equally to this work as co-senior authors.
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Science Translational Medicine 07 Nov 2018:
Vol. 10, Issue 466, eaat4921
DOI: 10.1126/scitranslmed.aat4921
Vol. 10, Issue 466, eaat4921
DOI: 10.1126/scitranslmed.aat4921
Florent Mouliere
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Dineika Chandrananda
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Anna M. Piskorz
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Elizabeth K. Moore
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.
James Morris
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Lise Barlebo Ahlborn
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.Centre for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Richard Mair
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, CB2 0QQ Cambridge, UK.
Teodora Goranova
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Francesco Marass
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.Swiss Institute of Bioinformatics, 4058 Basel, Switzerland.
Katrin Heider
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Jonathan C. M. Wan
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Anna Supernat
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Irena Hudecova
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Ioannis Gounaris
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.
Susana Ros
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Mercedes Jimenez-Linan
Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.
Javier Garcia-Corbacho
Clinical Trials Unit, Clinic Institute of Haematological and Oncological Diseases, Hospital Clinic de Barcelona, 170 08036 Barcelona, Spain.
Keval Patel
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Olga Østrup
Centre for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Suzanne Murphy
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Matthew D. Eldridge
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Davina Gale
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Grant D. Stewart
Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.Academic Urology Group, Department of Surgery, University of Cambridge, CB2 0QQ Cambridge, UK.
Johanna Burge
Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Academic Urology Group, Department of Surgery, University of Cambridge, CB2 0QQ Cambridge, UK.
Wendy N. Cooper
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
Michiel S. van der Heijden
Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
Charles E. Massie
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Department of Oncology, University of Cambridge, CB2 0XZ Cambridge, UK.
Colin Watts
Institute of Cancer Genomics Science, University of Birmingham, B15 2TT Birmingham, UK.
Pippa Corrie
Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.
Simon Pacey
Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.Department of Oncology, University of Cambridge, CB2 0XZ Cambridge, UK.
Kevin M. Brindle
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Department of Biochemistry, University of Cambridge, CB2 1QW Cambridge, UK.
Richard D. Baird
Early Phase Clinical Trials and Breast Cancer Research Teams, Cancer Research UK Cambridge Centre, CB2 0QQ Cambridge, UK.
Morten Mau-Sørensen
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Christine A. Parkinson
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, CB2 0XZ Cambridge, UK.NIHR Cambridge Biomedical Research Centre, CB2 0QQ Cambridge, UK.
Christopher G. Smith
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
James D. Brenton
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, CB2 0XZ Cambridge, UK.NIHR Cambridge Biomedical Research Centre, CB2 0QQ Cambridge, UK.
Nitzan Rosenfeld
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.