Research ArticleCancer

Enhanced detection of circulating tumor DNA by fragment size analysis

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Science Translational Medicine  07 Nov 2018:
Vol. 10, Issue 466, eaat4921
DOI: 10.1126/scitranslmed.aat4921

Article Information

vol. 10 no. 466

DOI: 
https://doi.org/10.1126/scitranslmed.aat4921
PubMed: 
30404863
Published By: 
American Association for the Advancement of Science
Print ISSN: 
1946-6234
Online ISSN: 
1946-6242
History: 
  • Received for publication March 29, 2018
  • Accepted for publication October 17, 2018
  • .
Copyright & Usage: 
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

Author Information

  1. Florent Mouliere1,2,*,†,
  2. Dineika Chandrananda1,2,*,
  3. Anna M. Piskorz1,2,*,
  4. Elizabeth K. Moore1,2,3,*,
  5. James Morris1,2,
  6. Lise Barlebo Ahlborn4,5,
  7. Richard Mair1,2,6,
  8. Teodora Goranova1,2,
  9. Francesco Marass1,2,7,8,
  10. Katrin Heider1,2,
  11. Jonathan C. M. Wan1,2,
  12. Anna Supernat1,2,9,
  13. Irena Hudecova1,2,
  14. Ioannis Gounaris1,2,3,
  15. Susana Ros1,2,
  16. Mercedes Jimenez-Linan2,3,
  17. Javier Garcia-Corbacho10,
  18. Keval Patel1,2,
  19. Olga Østrup5,
  20. Suzanne Murphy1,2,
  21. Matthew D. Eldridge1,2,
  22. Davina Gale1,2,
  23. Grant D. Stewart2,3,11,
  24. Johanna Burge2,11,
  25. Wendy N. Cooper1,2,
  26. Michiel S. van der Heijden12,13,
  27. Charles E. Massie1,2,14,
  28. Colin Watts15,
  29. Pippa Corrie3,
  30. Simon Pacey3,14,
  31. Kevin M. Brindle1,2,16,
  32. Richard D. Baird17,
  33. Morten Mau-Sørensen4,
  34. Christine A. Parkinson1,2,3,18,19,
  35. Christopher G. Smith1,2,
  36. James D. Brenton1,2,3,18,19,‡,§ and
  37. Nitzan Rosenfeld1,2,‡,§
  1. 1Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.
  2. 2Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, CB2 0RE Cambridge, UK.
  3. 3Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ Cambridge, UK.
  4. 4Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
  5. 5Centre for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
  6. 6Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, CB2 0QQ Cambridge, UK.
  7. 7Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.
  8. 8Swiss Institute of Bioinformatics, 4058 Basel, Switzerland.
  9. 9Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-211 Gdańsk, Poland.
  10. 10Clinical Trials Unit, Clinic Institute of Haematological and Oncological Diseases, Hospital Clinic de Barcelona, 170 08036 Barcelona, Spain.
  11. 11Academic Urology Group, Department of Surgery, University of Cambridge, CB2 0QQ Cambridge, UK.
  12. 12Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  13. 13Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  14. 14Department of Oncology, University of Cambridge, CB2 0XZ Cambridge, UK.
  15. 15Institute of Cancer Genomics Science, University of Birmingham, B15 2TT Birmingham, UK.
  16. 16Department of Biochemistry, University of Cambridge, CB2 1QW Cambridge, UK.
  17. 17Early Phase Clinical Trials and Breast Cancer Research Teams, Cancer Research UK Cambridge Centre, CB2 0QQ Cambridge, UK.
  18. 18Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, CB2 0XZ Cambridge, UK.
  19. 19NIHR Cambridge Biomedical Research Centre, CB2 0QQ Cambridge, UK.
  1. ↵§Corresponding author. Email: james.brenton{at}cruk.cam.ac.uk (J.D.B.); nitzan.rosenfeld{at}cruk.cam.ac.uk (N.R.)

    • ↵* These authors contributed equally to this work as co-first authors.

    • ↵† Present address: Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV Amsterdam, Netherlands.

    • ↵‡ These authors contributed equally to this work as co-senior authors.

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    • Enhanced detection of circulating tumor DNA by fragment size analysis

      By Florent Mouliere, Dineika Chandrananda, Anna M. Piskorz, Elizabeth K. Moore, James Morris, Lise Barlebo Ahlborn, Richard Mair, Teodora Goranova, Francesco Marass, Katrin Heider, Jonathan C. M. Wan, Anna Supernat, Irena Hudecova, Ioannis Gounaris, Susana Ros, Mercedes Jimenez-Linan, Javier Garcia-Corbacho, Keval Patel, Olga Østrup, Suzanne Murphy, Matthew D. Eldridge, Davina Gale, Grant D. Stewart, Johanna Burge, Wendy N. Cooper, Michiel S. van der Heijden, Charles E. Massie, Colin Watts, Pippa Corrie, Simon Pacey, Kevin M. Brindle, Richard D. Baird, Morten Mau-Sørensen, Christine A. Parkinson, Christopher G. Smith, James D. Brenton, Nitzan Rosenfeld

      Science Translational Medicine

      Selective sequencing or in silico analysis for differences in DNA fragment size can improve the detection of circulating tumor DNA.

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