07 November 2018
Vol 10, Issue 466

About The Cover

Cover image expansion

ONLINE COVER A Clearer Look at Tumor DNA. This stylized image of DNA represents a study by Mouliere et al. in which the authors demonstrated a sensitive way to detect tumor-derived DNA in patients' blood. Circulating pieces of DNA shed from healthy cells greatly outnumber tumor DNA fragments, which can make it difficult to detect tumor-derived DNA. The authors identified characteristic differences in the sizes of tumor and normal DNA fragments and showed that separating the fragments by size could enhance the detection of cancer DNA in patient plasma samples. A Focus by Heitzer et al. further discusses these findings. [CREDIT: GEOPAUL/GETTYIMAGES]