Contents
07 November 2018
Vol 10, Issue 466
Vol 10, Issue 466
Focus
- One size does not fit all: Size-based plasma DNA diagnostics
Understanding the biological properties of plasma cell-free DNA may expand its applications in oncology.
Research Articles
- Enhanced detection of circulating tumor DNA by fragment size analysis
Selective sequencing or in silico analysis for differences in DNA fragment size can improve the detection of circulating tumor DNA.
- Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration
Hydroxyapatite nodules in retinal drusen may indicate risk for progression to advanced age-related macular degeneration.
- Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand
Wnt1 is a physiologically relevant bone-anabolic molecule that does not require the expression of the bone-anabolic Wnt co-receptor Lrp5.
- 68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging
68Ga-DOTA-GGNle-CycMSHhex, a radiolabeled melanocortin-1 receptor–targeting imaging probe, detects melanoma in first-in-human testing.
Editors' Choice
- Music tunes the brain in autism
Music intervention alters brain activation and improves social communication skills in children with autism.
- Keeping pace with the mouse heart
A miniaturized and programmable pacemaker for mice demonstrates the feasibility of long-term cardiac pacing to study cardiac arrhythmias and heart failure.
- Exploiting human Tregs’ sweet tooth to improve cancer immunotherapy
TLR8 activation enhances cancer immunotherapy by reprograming of glucose metabolism in regulatory T cells.
Erratum
About The Cover
ONLINE COVER A Clearer Look at Tumor DNA. This stylized image of DNA represents a study by Mouliere et al. in which the authors demonstrated a sensitive way to detect tumor-derived DNA in patients' blood. Circulating pieces of DNA shed from healthy cells greatly outnumber tumor DNA fragments, which can make it difficult to detect tumor-derived DNA. The authors identified characteristic differences in the sizes of tumor and normal DNA fragments and showed that separating the fragments by size could enhance the detection of cancer DNA in patient plasma samples. A Focus by Heitzer et al. further discusses these findings. [CREDIT: GEOPAUL/GETTYIMAGES]