Research ArticleParkinson’s Disease

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

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Science Translational Medicine  31 Oct 2018:
Vol. 10, Issue 465, eaah4066
DOI: 10.1126/scitranslmed.aah4066

Article Information

vol. 10 no. 465

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 25, 2016
  • Resubmitted March 3, 2018
  • Accepted for publication August 23, 2018
  • .

Author Information

  1. Richard Gordon1,2,
  2. Eduardo A. Albornoz1,3,
  3. Daniel C. Christie1,
  4. Monica R. Langley4,
  5. Vinod Kumar1,
  6. Susanna Mantovani2,5,
  7. Avril A. B. Robertson3,6,
  8. Mark S. Butler3,
  9. Dominic B. Rowe7,
  10. Luke A. O’Neill8,
  11. Anumantha G. Kanthasamy4,
  12. Kate Schroder3,
  13. Matthew A. Cooper3,8,* and
  14. Trent M. Woodruff1,*
  1. 1School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, Queensland 4072, Australia.
  2. 2UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Herston, Queensland 4092, Australia.
  3. 3Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.
  4. 4Parkinson Disorders Research Program, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  5. 5Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Queensland 4006, Australia.
  6. 6School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
  7. 7Department of Neurology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
  8. 8School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Dublin 2, Ireland.
  1. *Corresponding author. Email: t.woodruff{at}uq.edu.au (T.M.W.); m.cooper{at}uq.edu.au (M.A.C.)

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