Research ArticleCancer

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

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Science Translational Medicine  24 Oct 2018:
Vol. 10, Issue 464, eaat3487
DOI: 10.1126/scitranslmed.aat3487

Article Information

vol. 10 no. 464

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 22, 2018
  • Accepted for publication October 1, 2018
  • .

Author Information

  1. Liran Zhou1,
  2. Hongmei Husted1,
  3. Todd Moore1,
  4. Mason Lu1,*,
  5. Defeng Deng2,,
  6. Yan Liu2,
  7. Vijaya Ramachandran2,
  8. Thiruvengadam Arumugam2,
  9. Christof Niehrs3,4,
  10. Huamin Wang5,
  11. Paul Chiao6,
  12. Jianhua Ling6,
  13. Michael A. Curran7,
  14. Anirban Maitra5,
  15. Mien-Chie Hung6,
  16. Jeffrey E. Lee1,
  17. Craig D. Logsdon2 and
  18. Rosa F. Hwang1,8,
  1. 1Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  3. 3Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany.
  4. 4Institute of Molecular Biology (IMB), 55128 Mainz, Germany.
  5. 5Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  6. 6Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  7. 7Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  8. 8Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. Corresponding author. Email: rhwang{at}mdanderson.org
  • * Present address: MedAbome Inc., 40515 Encyclopedia Circle, Fremont, CA 94538, USA.

  • Present address: Department of Otolaryngology-Research, Baylor College of Medicine, Houston, TX 77030, USA.

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