Research ArticleCancer

Systems biology–based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma

See allHide authors and affiliations

Science Translational Medicine  24 Oct 2018:
Vol. 10, Issue 464, eaat0150
DOI: 10.1126/scitranslmed.aat0150

Article Information

vol. 10 no. 464

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 26, 2018
  • Resubmitted June 26, 2018
  • Accepted for publication October 1, 2018
  • .

Author Information

  1. Lei Huang1,*,
  2. Sarah Garrett Injac2,3,*,
  3. Kemi Cui1,
  4. Frank Braun2,
  5. Qi Lin2,
  6. Yuchen Du2,
  7. Huiyuan Zhang2,
  8. Mari Kogiso2,
  9. Holly Lindsay2,3,
  10. Sibo Zhao2,3,
  11. Patricia Baxter2,3,
  12. Adesina Adekunle4,
  13. Tsz-Kwong Man3,
  14. Hong Zhao1,
  15. Xiao-Nan Li2,3,,
  16. Ching C. Lau3,,,§ and
  17. Stephen T. C. Wong1,
  1. 1Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute and Cancer Center, Weill Cornell Medicine, Houston, TX 77030, USA.
  2. 2Preclinical Neuro-Oncology Research Program, Baylor College of Medicine, Houston, TX 77030, USA.
  3. 3Texas Children’s Cancer and Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
  4. 4Department of Pathology, Texas Children’s Hospital, Houston, TX 77030, USA.
  1. Corresponding author. Email: stwong{at}houstonmethodist.org (S.T.C.W.); clau{at}connecticutchildrens.org (C.C.L.); xiaonan{at}bcm.edu (X.-N.L.)
    • * These authors contributed equally to this work.

    • Present address: Connecticut Children’s Medical Center, The University of Connecticut School of Medicine, Hartford, CT 06106, USA.

    • § Present address: The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.

    Altmetric

    Article usage

    Article usage: October 2018 to November 2019

    AbstractFullPdf
    Oct 20180110501901
    Nov 2018632788361
    Dec 2018376151113
    Jan 201928810075
    Feb 20192625743
    Mar 20192915439
    Apr 20192724127
    May 20192102128
    Jun 20191373729
    Jul 20192805743
    Aug 20193674122
    Sep 20193612517
    Oct 201927612624
    Nov 2019114530

    Navigate This Article