Research ArticleMUCOSAL IMMUNITY

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

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Science Translational Medicine  24 Oct 2018:
Vol. 10, Issue 464, eaao4755
DOI: 10.1126/scitranslmed.aao4755

Article Information

vol. 10 no. 464

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 30, 2017
  • Resubmitted June 19, 2018
  • Accepted for publication September 28, 2018
  • .

Author Information

  1. Nicholas A. Scott1,2,
  2. Anna Andrusaite3,
  3. Peter Andersen4,
  4. Melissa Lawson5,
  5. Cristina Alcon-Giner5,
  6. Charlotte Leclaire5,
  7. Shabhonam Caim5,
  8. Gwenaelle Le Gall5,
  9. Tovah Shaw1,2,
  10. James P. R. Connolly3,
  11. Andrew J. Roe3,
  12. Hannah Wessel3,
  13. Alberto Bravo-Blas3,
  14. Carolyn A. Thomson3,
  15. Verena Kästele3,
  16. Ping Wang1,
  17. Daniel A. Peterson4,6,
  18. Allison Bancroft1,7,
  19. Xuhang Li4,
  20. Richard Grencis1,7,
  21. Allan McI Mowat3,
  22. Lindsay J. Hall5,
  23. Mark A. Travis1,2,7,
  24. Simon W. F. Milling3,* and
  25. Elizabeth R. Mann1,2,3,*,
  1. 1Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, UK.
  2. 2Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.
  3. 3Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  4. 4Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  5. 5Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UA, UK.
  6. 6Eli Lilly and Company, Indianapolis, 46285 IN, USA.
  7. 7Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.
  1. Corresponding author. Email: elizabeth.mann{at}manchester.ac.uk
    • * These authors contributed equally to this work.

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