Research ArticleGUT MICROBIOTA
Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea
- View ORCID ProfileEric J. Battaglioli1,*,
- View ORCID ProfileVanessa L. Hale2,3,*,
- Jun Chen4,
- View ORCID ProfilePatricio Jeraldo2,
- Coral Ruiz-Mojica1,
- Bradley A. Schmidt1,
- View ORCID ProfileVayu M. Rekdal1,
- View ORCID ProfileLisa M. Till1,
- View ORCID ProfileLutfi Huq2,
- View ORCID ProfileSamuel A. Smits5,
- William J. Moor1,
- View ORCID ProfileYava Jones-Hall6,
- View ORCID ProfileThomas Smyrk7,
- Sahil Khanna1,
- Darrell S. Pardi1,
- View ORCID ProfileMadhusudan Grover1,
- Robin Patel8,
- Nicholas Chia2,
- Heidi Nelson2,
- View ORCID ProfileJustin L. Sonnenburg5,
- View ORCID ProfileGianrico Farrugia9 and
- View ORCID ProfilePurna C. Kashyap1,10,†
- 1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
- 2Department of Surgery, Mayo Clinic, Rochester, MN, USA.
- 3Department of Veterinary Preventive Medicine, Ohio State University, Columbus, OH, USA.
- 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
- 5Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
- 6Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
- 7Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
- 8Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.
- 9Division of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
- 10Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
- ↵†Corresponding author. Email: kashyap.purna{at}mayo.edu
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 24 Oct 2018:
Vol. 10, Issue 464, eaam7019
DOI: 10.1126/scitranslmed.aam7019
Vol. 10, Issue 464, eaam7019
DOI: 10.1126/scitranslmed.aam7019
Eric J. Battaglioli
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Vanessa L. Hale
2Department of Surgery, Mayo Clinic, Rochester, MN, USA.
3Department of Veterinary Preventive Medicine, Ohio State University, Columbus, OH, USA.
Jun Chen
4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Patricio Jeraldo
2Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Coral Ruiz-Mojica
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Bradley A. Schmidt
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Vayu M. Rekdal
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Lisa M. Till
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Lutfi Huq
2Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Samuel A. Smits
5Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
William J. Moor
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Yava Jones-Hall
6Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
Thomas Smyrk
7Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
Sahil Khanna
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Darrell S. Pardi
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Madhusudan Grover
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Robin Patel
8Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.
Nicholas Chia
2Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Heidi Nelson
2Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Justin L. Sonnenburg
5Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Gianrico Farrugia
9Division of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
Purna C. Kashyap
1Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
10Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
