Research ArticleGUT MICROBIOTA

Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea

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Science Translational Medicine  24 Oct 2018:
Vol. 10, Issue 464, eaam7019
DOI: 10.1126/scitranslmed.aam7019

To infect or not to infect?

Our gut harbors a diverse microbial community that efficiently uses nutrients. Battaglioli et al. now report that a subset of patients with diarrhea show increased availability of gut amino acids due to deleterious changes in the gut microbiota (dysbiosis). These dysbiotic microbial communities when modeled in germ-free mice exhibited increased susceptibility to Clostridioides difficile, a pathogen that uses amino acids as a nutrient source. Prophylactic fecal microbiota transplant from healthy humans to mice with a dysbiotic gut microbiota restored microbial diversity and protected the mice from C. difficile infection.

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