Research ArticleMUCOSAL IMMUNITY

A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans

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Science Translational Medicine  17 Oct 2018:
Vol. 10, Issue 463, eaat0797
DOI: 10.1126/scitranslmed.aat0797

Article Information

vol. 10 no. 463

PubMed: 
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History: 
  • Received for publication January 22, 2018
  • Resubmitted July 3, 2018
  • Accepted for publication September 13, 2018
  • .

Author Information

  1. Nicolas Dutzan1,2,
  2. Tetsuhiro Kajikawa3,*,
  3. Loreto Abusleme1,2,*,
  4. Teresa Greenwell-Wild1,
  5. Carlos E. Zuazo1,
  6. Tomoko Ikeuchi1,
  7. Laurie Brenchley1,
  8. Toshiharu Abe3,
  9. Charlotte Hurabielle4,5,
  10. Daniel Martin6,
  11. Robert J. Morell6,
  12. Alexandra F. Freeman7,
  13. Vanja Lazarevic8,
  14. Giorgio Trinchieri9,
  15. Patricia I. Diaz10,
  16. Steven M. Holland7,
  17. Yasmine Belkaid4,
  18. George Hajishengallis3, and
  19. Niki M. Moutsopoulos1,,
  1. 1Oral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.
  2. 2Faculty of Dentistry, University of Chile, 8380492 Santiago, Chile.
  3. 3Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  4. 4Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, MD 20892, USA.
  5. 5Inserm U976, Hôpital Saint Louis, Université Paris Diderot, Paris 75010, France.
  6. 6Genomics and Computational Biology Core, NIDCD, NIH, Bethesda, MD 20892, USA.
  7. 7Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD 20892, USA.
  8. 8Experimental Immunology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
  9. 9Cancer and Inflammation Program, CCR, NCI, NIH, Bethesda, MD 20892, USA.
  10. 10School of Dental Medicine, UConn Health, Farmington, CT 06030, USA.
  1. Corresponding author. Email: nmoutsop{at}mail.nih.gov
    • * These authors contributed equally to this work.

    • Senior authors.

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