17 October 2018
Vol 10, Issue 463

About The Cover

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ONLINE COVER Smile! Oral health can be taken for granted, but many people are afflicted by periodontitis, an inflammatory disease that can lead to jaw bone loss. Dutzan et al. studied samples from humans and a mouse model of periodontitis to understand disease development. They discovered that T helper 17 (TH17) cells driven by the microbiome were pathogenic, and targeting these cells relieved periodontitis symptoms in mice. People naturally deficient in TH17 cells were less likely to develop periodontitis. As TH17-targeting small molecules are being developed clinically, these results could lead to a therapy that gives periodontitis patients something to smile about. [CREDIT: ZOLJO/ISTOCK.COM]