Research ArticleOsteoarthritis
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
- Eun Kyung Song1,2,*,
- Jimin Jeon3,4,5,*,
- Dong Gil Jang1,
- Ha Eun Kim1,
- Hyo Jung Sim1,
- Keun Yeong Kwon1,
- Sofia Medina-Ruiz6,
- Hyun-Jun Jang1,
- Ah Reum Lee1,
- Jun Gi Rho7,
- Hyun-Shik Lee8,
- Seok Jung Kim9,
- Chan Young Park1,
- Kyungjae Myung2,
- Wook Kim7,
- Taejoon Kwon1,
- Siyoung Yang3,4,5,† and
- Tae Joo Park1,2,†
- 1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
- 2Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
- 3Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
- 4Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea.
- 5CIRNO, Sungkyunkwan University, Suwon 16419, Republic of Korea.
- 6Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
- 7Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
- 8KNU-Center for Nonlinear Dynamics, CMRI, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
- 9Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
- ↵†Corresponding author. Email: parktj{at}unist.ac.kr (T.J.P.); yangsy{at}ajou.ac.kr (S.Y.)
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Science Translational Medicine 10 Oct 2018:
Vol. 10, Issue 462, eaam7486
DOI: 10.1126/scitranslmed.aam7486
