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Research ArticleOsteoarthritis
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
- View ORCID ProfileEun Kyung Song1,2,*,
- View ORCID ProfileJimin Jeon3,4,5,*,
- View ORCID ProfileDong Gil Jang1,
- View ORCID ProfileHa Eun Kim1,
- View ORCID ProfileHyo Jung Sim1,
- View ORCID ProfileKeun Yeong Kwon1,
- Sofia Medina-Ruiz6,
- View ORCID ProfileHyun-Jun Jang1,
- Ah Reum Lee1,
- Jun Gi Rho7,
- Hyun-Shik Lee8,
- View ORCID ProfileSeok Jung Kim9,
- View ORCID ProfileChan Young Park1,
- Kyungjae Myung2,
- Wook Kim7,
- View ORCID ProfileTaejoon Kwon1,
- View ORCID ProfileSiyoung Yang3,4,5,† and
- View ORCID ProfileTae Joo Park1,2,†
- 1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
- 2Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
- 3Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
- 4Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea.
- 5CIRNO, Sungkyunkwan University, Suwon 16419, Republic of Korea.
- 6Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
- 7Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
- 8KNU-Center for Nonlinear Dynamics, CMRI, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
- 9Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
- ↵†Corresponding author. Email: parktj{at}unist.ac.kr (T.J.P.); yangsy{at}ajou.ac.kr (S.Y.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 10 Oct 2018:
Vol. 10, Issue 462, eaam7486
DOI: 10.1126/scitranslmed.aam7486
Vol. 10, Issue 462, eaam7486
DOI: 10.1126/scitranslmed.aam7486
Eun Kyung Song
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
2Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Jimin Jeon
3Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
4Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea.
5CIRNO, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Dong Gil Jang
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Ha Eun Kim
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Hyo Jung Sim
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Keun Yeong Kwon
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Sofia Medina-Ruiz
6Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Hyun-Jun Jang
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Ah Reum Lee
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Jun Gi Rho
7Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
Hyun-Shik Lee
8KNU-Center for Nonlinear Dynamics, CMRI, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Seok Jung Kim
9Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Chan Young Park
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Kyungjae Myung
2Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Wook Kim
7Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
Taejoon Kwon
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Siyoung Yang
3Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
4Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea.
5CIRNO, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Tae Joo Park
1School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
2Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
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