Research ArticleHIV

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

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Science Translational Medicine  03 Oct 2018:
Vol. 10, Issue 461, eaau4711
DOI: 10.1126/scitranslmed.aau4711

Article Information

vol. 10 no. 461

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 13, 2018
  • Accepted for publication September 11, 2018
  • .

Author Information

  1. Mathieu Uzzan1,2,
  2. Minami Tokuyama3,
  3. Adam K. Rosenstein1,2,
  4. Costin Tomescu4,
  5. Ivo N. SahBandar5,
  6. Huaibin M. Ko2,3,
  7. Louise Leyre6,
  8. Anupa Chokola7,
  9. Emma Kaplan-Lewis8,
  10. Gabriela Rodriguez8,
  11. Akihiro Seki1,2,
  12. Michael J. Corley5,
  13. Judith Aberg8,
  14. Annalena La Porte7,8,
  15. Eun-young Park5,
  16. Hideki Ueno7,
  17. Ioannis Oikonomou9,
  18. Itai Doron10,
  19. Iliyan D. Iliev10,
  20. Benjamin K. Chen1,7,8,
  21. Jennifer Lui1,2,
  22. Timothy W. Schacker11,
  23. Glaucia C. Furtado1,
  24. Sergio A. Lira1,
  25. Jean-Frederic Colombel2,
  26. Amir Horowitz1,
  27. Jean K. Lim8,
  28. Nicolas Chomont6,
  29. Adeeb H. Rahman12,13,
  30. Luis J. Montaner4,
  31. Lishomwa C. Ndhlovu5 and
  32. Saurabh Mehandru1,2,*
  1. 1Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  2. 2Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  3. 3Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  4. 4Wistar Institute, Philadelphia, PA 19104, USA.
  5. 5Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
  6. 6Centre de recherche du Centre hospitalier de l’Université de Montréal and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, Québec H2X 0A9, Canada.
  7. 7Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  8. 8Division of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  9. 9Division of Gastroenterology, Rush University, Chicago, IL 60612, USA.
  10. 10Gastroenterology and Hepatology Divison, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
  11. 11Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
  12. 12Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  13. 13Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  1. *Corresponding author. Email: saurabh.mehandru{at}mssm.edu

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