Research ArticleHuntington’s Disease
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
- Amber L. Southwell1,*,
- Holly B. Kordasiewicz2,
- Douglas Langbehn3,
- Niels H. Skotte1,†,
- Matthew P. Parsons4,‡,
- Erika B. Villanueva1,§,
- Nicholas S. Caron1,
- Michael E. Østergaard2,
- Lisa M. Anderson1,
- Yuanyun Xie1,
- Louisa Dal Cengio1,
- Hailey Findlay-Black1,
- Crystal N. Doty1,
- Bethany Fitsimmons2,
- Eric E. Swayze2,
- Punit P. Seth2,
- Lynn A. Raymond4,
- C. Frank Bennett2 and
- Michael R. Hayden1,¶
- 1Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
- 2Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
- 3Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
- 4Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
- ↵¶Corresponding author. Email: mrh{at}cmmt.ubc.ca
↵* Present address: Burnett School of Biomedical Sciences, Division of Neuroscience, University of Central Florida, Orlando, FL 32827, USA.
↵† Present address: Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
↵‡ Present address: Faculty of Medicine, Division of Biomedical Sciences, Memorial University, St. John’s, Newfoundland A1C 5S7, Canada.
↵§ Present address: Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen 2200, Denmark.
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Science Translational Medicine 03 Oct 2018:
Vol. 10, Issue 461, eaar3959
DOI: 10.1126/scitranslmed.aar3959
Vol. 10, Issue 461, eaar3959
DOI: 10.1126/scitranslmed.aar3959
Amber L. Southwell
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Holly B. Kordasiewicz
Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
Douglas Langbehn
Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Niels H. Skotte
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Matthew P. Parsons
Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Erika B. Villanueva
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Nicholas S. Caron
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Michael E. Østergaard
Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
Lisa M. Anderson
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Yuanyun Xie
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Louisa Dal Cengio
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Hailey Findlay-Black
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Crystal N. Doty
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Bethany Fitsimmons
Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
Eric E. Swayze
Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
Punit P. Seth
Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
Lynn A. Raymond
Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
C. Frank Bennett
Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
Michael R. Hayden
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
