Research ArticleHuntington’s Disease

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

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Science Translational Medicine  03 Oct 2018:
Vol. 10, Issue 461, eaar3959
DOI: 10.1126/scitranslmed.aar3959

Article Information

vol. 10 no. 461

Print ISSN: 
Online ISSN: 
  • Received for publication November 3, 2017
  • Resubmitted May 26, 2018
  • Accepted for publication September 12, 2018

Author Information

  1. Amber L. Southwell1,*,
  2. Holly B. Kordasiewicz2,
  3. Douglas Langbehn3,
  4. Niels H. Skotte1,,
  5. Matthew P. Parsons4,,
  6. Erika B. Villanueva1,§,
  7. Nicholas S. Caron1,
  8. Michael E. Østergaard2,
  9. Lisa M. Anderson1,
  10. Yuanyun Xie1,
  11. Louisa Dal Cengio1,
  12. Hailey Findlay-Black1,
  13. Crystal N. Doty1,
  14. Bethany Fitsimmons2,
  15. Eric E. Swayze2,
  16. Punit P. Seth2,
  17. Lynn A. Raymond4,
  18. C. Frank Bennett2 and
  19. Michael R. Hayden1,
  1. 1Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
  2. 2Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
  3. 3Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  4. 4Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  1. Corresponding author. Email: mrh{at}
  • * Present address: Burnett School of Biomedical Sciences, Division of Neuroscience, University of Central Florida, Orlando, FL 32827, USA.

  • Present address: Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.

  • Present address: Faculty of Medicine, Division of Biomedical Sciences, Memorial University, St. John’s, Newfoundland A1C 5S7, Canada.

  • § Present address: Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen 2200, Denmark.


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