03 October 2018
Vol 10, Issue 461
  • Perspective

    • Regulating 3D-printed medical products

      There are a number of key considerations in the U.S. regulatory landscape regarding approval of 3D-printed medical devices and biologics.

  • Research Articles

  • Editors' Choice

    • Astrocyte dysfunction and compulsive behavior

      Molecular, cellular, and circuit physiology studies identify a potential new therapeutic target for compulsive behavior disorders, involving dysfunctional neuron-astrocyte interactions within striatal microcircuits.

About The Cover

Cover image expansion

ONLINE COVER Aggravating Aggregates. Eradicating HIV in infected patients will likely require disrupting the reservoir of infected T cells in the gastrointestinal tract. One approach may be targeting cells expressing the integrin α4β7. Uzzan et al. studied patients with inflammatory bowel disease (IBD) that were also infected with HIV. They found that anti-α4β7 therapy (an approved therapy for IBD) disrupted lymphoid aggregates in the gut, such as the one pictured here. The anti-integrin therapy was well-tolerated and could possibly be used to root out HIV in the gut. [CREDIT: UZZAN ET AL./MOUNT SINAI SCHOOL OF MEDICINE]