Research ArticleFibrosis

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

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Science Translational Medicine  26 Sep 2018:
Vol. 10, Issue 460, eaar8356
DOI: 10.1126/scitranslmed.aar8356

Article Information

vol. 10 no. 460

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 21, 2017
  • Resubmitted May 2, 2018
  • Accepted for publication September 5, 2018
  • .

Author Information

  1. Lindsay J. Celada1,*,
  2. Jonathan A. Kropski2,
  3. Jose D. Herazo-Maya3,
  4. Weifeng Luo1,
  5. Amy Creecy4,
  6. Andrew T. Abad1,
  7. Ozioma S. Chioma1,
  8. Grace Lee1,
  9. Natalie E. Hassell1,
  10. Guzel I. Shaginurova1,
  11. Yufen Wang1,
  12. Joyce E. Johnson5,
  13. Amy Kerrigan1,
  14. Wendi R. Mason2,
  15. Robert P. Baughman6,
  16. Gregory D. Ayers7,
  17. Gordon R. Bernard2,
  18. Daniel A. Culver8,
  19. Courtney G. Montgomery4,9,
  20. Toby M. Maher10,11,
  21. Philip L. Molyneaux10,11,
  22. Imre Noth12,
  23. Steven E. Mutsaers13,14,
  24. Cecilia M. Prele13,14,
  25. R. Stokes Peebles Jr.2,5,
  26. Dawn C. Newcomb2,5,
  27. Naftali Kaminski3,
  28. Timothy S. Blackwell2,
  29. Luc Van Kaer5 and
  30. Wonder P. Drake1,5,*
  1. 1Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  2. 2Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  3. 3Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  4. 4Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
  5. 5Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  6. 6Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45219, USA.
  7. 7Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  8. 8Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  9. 9Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA.
  10. 10National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton Hospital, London SW7 2AZ, UK.
  11. 11Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.
  12. 12Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA.
  13. 13Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
  14. 14Institute for Respiratory Health, Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
  1. *Corresponding author. Email: wonder.drake{at}vanderbilt.edu (W.P.D.); lindsay.j.celada{at}vanderbilt.edu (L.J.C.)

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