Research ArticleMalaria
Prime and target immunization protects against liver-stage malaria in mice
- View ORCID ProfileAnita Gola1,2,
- View ORCID ProfileDaniel Silman1,3,
- Adam A. Walters1,
- Saranya Sridhar1,3,
- View ORCID ProfileStefan Uderhardt2,
- Ahmed M. Salman1,4,
- Benedict R. Halbroth1,
- View ORCID ProfileDuncan Bellamy1,
- View ORCID ProfileGeorgina Bowyer1,
- Jonathan Powlson1,
- Megan Baker1,3,
- Navin Venkatraman1,3,
- View ORCID ProfileIan Poulton1,3,
- View ORCID ProfileEleanor Berrie5,
- Rachel Roberts1,3,
- Alison M. Lawrie1,3,
- View ORCID ProfileBrian Angus6,
- View ORCID ProfileShahid M. Khan4,
- Chris J. Janse4,
- View ORCID ProfileKatie J. Ewer1,
- View ORCID ProfileRonald N. Germain2,
- Alexandra J. Spencer1 and
- Adrian V. S. Hill1,*
- 1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
- 2Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
- 4Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
- 5Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford OX3 7JT, UK.
- 6Nuffield Department of Medicine, University of Oxford, Oxford, UK.
- ↵*Corresponding author. Email: adrian.hill{at}ndm.ox.ac.uk
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Science Translational Medicine 26 Sep 2018:
Vol. 10, Issue 460, eaap9128
DOI: 10.1126/scitranslmed.aap9128
Vol. 10, Issue 460, eaap9128
DOI: 10.1126/scitranslmed.aap9128
Anita Gola
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
2Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Daniel Silman
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Adam A. Walters
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Saranya Sridhar
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Stefan Uderhardt
2Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ahmed M. Salman
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
4Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Benedict R. Halbroth
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Duncan Bellamy
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Georgina Bowyer
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Jonathan Powlson
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Megan Baker
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Navin Venkatraman
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Ian Poulton
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Eleanor Berrie
5Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford OX3 7JT, UK.
Rachel Roberts
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Alison M. Lawrie
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
Brian Angus
6Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Shahid M. Khan
4Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Chris J. Janse
4Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Katie J. Ewer
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Ronald N. Germain
2Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alexandra J. Spencer
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Adrian V. S. Hill
1Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
