Prime and target immunization protects against liver-stage malaria in mice

Anita Gola; Daniel Silman; Adam A. Walters; Saranya Sridhar; Stefan Uderhardt; Ahmed M. Salman; Benedict R. Halbroth; Duncan Bellamy; Georgina Bowyer; Jonathan Powlson; Megan Baker; Navin Venkatraman; Ian Poulton; Eleanor Berrie; Rachel Roberts; Alison M. Lawrie; Brian Angus; Shahid M. Khan; Chris J. Janse; Katie J. Ewer; Ronald N. Germain; Alexandra J. Spencer; Adrian V. S. Hill

doi:10.1126/scitranslmed.aap9128

Research ArticleMalaria

Prime and target immunization protects against liver-stage malaria in mice

Anita Gola ¹,²,
Daniel Silman¹,³,
Adam A. Walters¹,
Saranya Sridhar¹,³,
Stefan Uderhardt²,
Ahmed M. Salman¹,⁴,
Benedict R. Halbroth¹,
Duncan Bellamy¹,
Georgina Bowyer¹,
Jonathan Powlson¹,
Megan Baker¹,³,
Navin Venkatraman¹,³,
Ian Poulton¹,³,
Eleanor Berrie⁵,
Rachel Roberts¹,³,
Alison M. Lawrie¹,³,
Brian Angus⁶,
Shahid M. Khan⁴,
Chris J. Janse⁴,
Katie J. Ewer¹,
Ronald N. Germain ²,
Alexandra J. Spencer¹ and
Adrian V. S. Hill ¹,*

¹Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
²Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
³Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
⁴Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
⁵Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford OX3 7JT, UK.
⁶Nuffield Department of Medicine, University of Oxford, Oxford, UK.

↵*Corresponding author. Email: adrian.hill{at}ndm.ox.ac.uk

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Science Translational Medicine 26 Sep 2018:
Vol. 10, Issue 460, eaap9128
DOI: 10.1126/scitranslmed.aap9128

Anita Gola

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Daniel Silman

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.

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Adam A. Walters

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Saranya Sridhar

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Stefan Uderhardt

Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Ahmed M. Salman

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

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Benedict R. Halbroth

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Duncan Bellamy

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Georgina Bowyer

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Jonathan Powlson

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Megan Baker

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Navin Venkatraman

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Ian Poulton

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Eleanor Berrie

Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford OX3 7JT, UK.

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Rachel Roberts

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Alison M. Lawrie

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Brian Angus

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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Shahid M. Khan

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

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Chris J. Janse

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

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Katie J. Ewer

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Ronald N. Germain

Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Alexandra J. Spencer

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Adrian V. S. Hill

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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For correspondence: adrian.hill@ndm.ox.ac.uk

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