26 September 2018
Vol 10, Issue 460

About The Cover

Cover image expansion

ONLINE COVER Mechanism of Malady. Progeria is a disease of premature aging caused by the production of a truncated form of prelamin A (progerin). Shown here is a colored transmission electron microscopy image of an aortic smooth muscle cell (SMC) from a mouse with progeria. Kim et al. studied vascular dysfunction in progeria, revealing that progerin expression and mechanical strain induced cell death in SMCs. Disrupting the link between the cytoskeleton and nuclear lamina in progerin-expressing SMCs improved aortic pathology by reducing shear stress transmission. This study helps identify the mechanism of arterial pathology in Hutchinson-Gilford progeria syndrome.[CREDIT: KIM ET AL./UNIVERSITY OF CALIFORNIA, LOS ANGELES]